"Ctf2" Related Products

Recombinant Mouse Cardiotrophin 2

Cat. No.: Ctf2-952M
Product Overview: Recombinant mouse Neuropoietin produced inE.Coliis a 19.8 kDa protein containing 183 amino acid residues.
Description: Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure, and signal through gp130-containing receptor complexes. Neuropoietin, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and could increase the proliferation of neural precursor cells in the presence of EGF and FGF-2. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway.
Source: E.Coli.
Purity: > 98% by SDS-PAGE.
Endotoxin Level: < 0.1 ng per μg of Neuropoietin.
Stabilizer: None.
Formulation: Lyophilized.
Biological Activity: The ED50was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 μg/ml.
Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Neuropoietin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles.
Gene Name: Ctf2 cardiotrophin 2 [ Mus musculus ]
Synonyms: cardiotrophin 2; NP; Gm494; Ctf2; neuropoietin; LOC244218
Gene ID: 244218
mRNA Refseq: NM_198858
Protein Refseq: NP_942155
UniProt ID: P83714
Chromosome Location: 7 F3
Function: ciliary neurotrophic factor receptor binding; leukemia inhibitory factor receptor binding; cytokine activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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