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Recombinant Human Toll-like Receptor 3

Cat.No. : TLR3-975H
Product Overview : Recombinant human TLR-3 produced in293 cellsis 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.
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  • Gene Information
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Cat. No. : TLR3-975H
Description : TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells.
Source : 293 cells.
Purity : 95 % (SDS-PAGE, HPLC).
Endotoxin level : < 0.1 ng per μg of TLR-3.
Stabilizer : None.
Formulation : Lyophilized.
Biologically Activity : Determined by its ability to inhibit IL-8 secretion induced by Poly I:C in the TLR3 receptor-expressing HEK293 cells (HEK293 TLR3r). The ED50for this effect is ≤ 30 μg/ml in the presence of 100 μg/ml of Poly I:C.
Stability : The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TLR-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles.
Gene Name : TLR3 toll-like receptor 3 [ Homo sapiens ]
Synonyms : TLR3; toll-like receptor 3; CD283
Gene ID : 7098
mRNA Refseq : NM_003265
Protein Refseq : NP_003256
MIM : 603029
UniProt ID : O15455
Chromosome Location : 4q35
pathway : Toll-like receptor signaling pathway
Function : double-stranded RNA binding; protein binding; transmembrane receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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