Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human Growth Differentiation Factor 15

Cat.No. : GDF15-243H
Product Overview : Recombinant Human GDF-15/MIC-1 produced inCell cultureis a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : GDF15-243H
Description : GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
Source : Cell culture.
Purity : 98 % (SDS-PAGE, HPLC).
Endotoxin level : < 0.1 ng per μg of GDF-15/MIC-1.
Stabilizer : None.
Formulation : Lyophilized.
Biologically Activity : Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 μg/ml.
Stability : The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted GDF-15/MIC-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles.
Gene Name : GDF15 growth differentiation factor 15 [ Homo sapiens ]
Synonyms : GDF15; growth differentiation factor 15; PDF; MIC1; PLAB; MIC-1;NAG-1; PTGFB; GDF-15; PTGF-beta; prostate differentiation factor; NSAID(nonsteroidal anti-inflammatory drug)-activatedprotein 1; NRG-1; Macrophage inhibitory cytokine 1; NSAID-activated gene1 protein; NSAID-regulated gene 1 protein; Placental TGF-beta; Placentalbone morphogeneticprotein;Growth/differentiation factor 15
Gene ID : 9518
mRNA Refseq : NM_004864
Protein Refseq : NP_004855
MIM : 605312
UniProt ID : Q99988
Chromosome Location : 19p13.11
Function : cytokine activity; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does GDF15 play in cardiovascular diseases, particularly in heart failure and atherosclerosis? 08/14/2022

GDF15 influences cardiovascular health, impacting heart failure progression and atherosclerotic processes.

How does GDF15 influence inflammatory processes and immune responses in chronic diseases? 07/17/2022

GDF15 modulates inflammatory and immune responses, crucial in the context of chronic diseases.

How does GDF15 contribute to tissue repair and fibrosis in organs like the liver and kidneys? 10/16/2021

GDF15 contributes to tissue repair and fibrosis, particularly in liver and kidney pathologies.

What is the impact of GDF15 on cancer development and progression, especially in terms of tumor microenvironment modulation? 05/18/2021

GDF15 affects cancer development by altering the tumor microenvironment and influencing tumor cell behavior.

How do alterations in GDF15 expression impact aging and age-related pathologies? 07/14/2018

Changes in GDF15 expression are linked to aging and age-related diseases, affecting various physiological processes.

How does GDF15 regulate energy metabolism and appetite in the context of obesity and metabolic disorders? 04/21/2018

GDF15 is involved in regulating energy metabolism and appetite, playing a key role in obesity and metabolic syndromes.

What are the mechanisms by which GDF15 affects cellular stress responses and apoptosis? 03/05/2018

GDF15 is involved in cellular stress responses, influencing apoptosis and cell survival mechanisms.

Customer Reviews (3)

Write a review
Reviews
03/19/2021

    Dependable protein purification, consistent and cost-effective.

    07/29/2019

      Precise mass spectrometry analysis, key for proteomics research.

      02/22/2019

        Great antibody validation, enhances our immunoprecipitation experiments.

        Ask a Question for All GDF15 Products

        Required fields are marked with *

        My Review for All GDF15 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends