Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 3 NR1I3-1020H

Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 3

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Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 3

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Cat. No. : NR1I3-1020H
Description : The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively acitve, it can be further activated by 'phenobarbitol-like' compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, has been shown to place a role in bile acid clearance and cholestatic liver injury.
Source : E. coli.
Form : Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol.
Purity : > 95% by SDS-PAGE.
Activity : 20-200 ng are sufficient for an in vitro transcription assay and 100 ng are sufficient for a protein-protein interaction assay.
Application : Use only for research. CAR can be applied in in vitro transcription assays, DNA-protein and protein-protein interaction assays.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles.
PDB rendering based on 1xv9. :

Gene Name : NR1I3 nuclear receptor subfamily 1, group I, member 3 [ Homo sapiens ]
Synonyms : NR1I3; nuclear receptor subfamily 1, group I, member 3; CAR; CAR1; MB67; MGC97144; MGC97209; MGC150433; constitutive androstane receptor; OTTHUMP00000032246; constitutive active receptor; orphan nuclear hormone receptor; constitutive activator of retinoid response; Nuclear receptor subfamily 1 group I member 3; Orphan nuclear receptor MB67; OTTHUMP00000032245
Gene ID : 9970
mRNA Refseq : NM_001077469
Protein Refseq : NP_001070937
MIM : 603881
UniProt ID : Q14994
Chromosome Location : 1q23.3
Function : androgen receptor activity; metal ion binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; zinc ion binding

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