"RAPGEF3" Related Products


Recombinant Human Rap guanine nucleotide exchange factor (GEF) 3

Cat. No.: RAPGEF3-1032H
Description: EPAC (exchange protein directly activated by cAMP) is a Rap-specific guanine-nucleotide exchange factor (GEF). EPAC is activated by the binding of cAMP to a cyclic nucleotide monophosphate-binding domain. N-terminal deletion of the DEP domain (domain that occur in Dishevelled, Egl-10, and Pleckstrin) of EPAC _DEP does not affect regulation of EPAC-activity but affects membrane localization.
Source: E. coli.
Usage: For in vitro use only.
Form: Liquid. Supplied in 50 mM Tris-HCl pH 7.6, 50 mM NaCl, 5 mM DTE and 5 % glycerol.
Purity: > 95% by SDS-PAGE.
Storage: Quality guaranteed for 12 months, Store at -80°C. Avoid freeze / thaw cycles.
Gene Name: RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 [ Homo sapiens ]
Synonyms: RAPGEF3; Rap guanine nucleotide exchange factor (GEF) 3; EPAC; EPAC1; bcm910; HSU79275; MGC21410; CAMP-GEFI; Rap guanine nucleotide exchange factor 3; 9330170P05Rik; exchange protein directly activated by cAMP 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP;cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; Epac 1
Gene ID: 10411
mRNA Refseq: NM_001098531
Protein Refseq: NP_001092001
MIM: 606057
UniProt ID: O95398
Chromosome Location: 12q13.1
Pathway: Leukocyte transendothelial migration; Long-term potentiation; Diabetes pathways; Hemostasis; Integrin cell surface interactions
Function: cAMP binding; cAMP-dependent protein kinase regulator activity; guanyl-nucleotide exchange factor activity; nucleotide binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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