Recombinant Human Rap guanine nucleotide exchange factor (GEF) 3

• Cat.No.: RAPGEF3-1032H

Specification

• Cat. No.: RAPGEF3-1032H
• Description: EPAC (exchange protein directly activated by cAMP) is a Rap-specific guanine-nucleotide exchange factor (GEF). EPAC is activated by the binding of cAMP to a cyclic nucleotide monophosphate-binding domain. N-terminal deletion of the DEP domain (domain that occur in Dishevelled, Egl-10, and Pleckstrin) of EPAC _DEP does not affect regulation of EPAC-activity but affects membrane localization.
• Source: E. coli.
• Usage: For in vitro use only.
• Form: Liquid. Supplied in 50 mM Tris-HCl pH 7.6, 50 mM NaCl, 5 mM DTE and 5 % glycerol.
• Purity: > 95% by SDS-PAGE.
• Storage: Quality guaranteed for 12 months, Store at -80°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 [ Homo sapiens ]
• Synonyms: RAPGEF3; Rap guanine nucleotide exchange factor (GEF) 3; EPAC; EPAC1; bcm910; HSU79275; MGC21410; CAMP-GEFI; Rap guanine nucleotide exchange factor 3; 9330170P05Rik; exchange protein directly activated by cAMP 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP;cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; Epac 1
• Gene ID: 10411
• mRNA Refseq: NM_001098531
• Protein Refseq: NP_001092001
• MIM: 606057
• UniProt ID: O95398
• Chromosome Location: 12q13.1
• Pathway: Leukocyte transendothelial migration; Long-term potentiation; Diabetes pathways; Hemostasis; Integrin cell surface interactions
• Function: cAMP binding; cAMP-dependent protein kinase regulator activity; guanyl-nucleotide exchange factor activity; nucleotide binding