"PYCR2" Related Products

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Pyrroline-5-carboxylate Reductase 2

Cat. No.: CBCRY25
Background: Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis.
Protein Classification: Oxidoreductase
Structure Weight: 149791.08 Da
Polymer: 1
Molecule: Pyrroline-5-carboxylate reductase 2
Chain Length: 277 amino acids
PDB ID: 2GR9
MMDB ID: 41570
Source: E.coli
Method: X-Ray Diffraction
Resolution: 3.1Å
Ligand Chemical Component: Magnesium ion; Sulfate ion
Reference: Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377
Gene Name: PYCR2
Synonyms: P5CR2; OTTHUMP00000035614; pyrroline 5-carboxylate reductase isoform; EC 1.5.1.2; P5C reductase 2; pyrroline-5-carboxylate reductase family, member 2; FLJ54750; RP4-559A3.4
UniProt ID: Q96C36
Gene ID: 29920
Chromosome Location: 1q42.12
Function: catalytic activity; binding; pyrroline-5-carboxylate reductase activity; Oxidoreductase activity

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