Recombinant Human PNPLA2, His-tagged
Cat.No. : | PNPLA2-322H |
Product Overview : | A DNA sequence encoding the human ATGL (Met1-Leu504) with 6 His tag on the N-Terminus was expressed in E. Coli. This protein was purified by Ni-NTA column. |
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- Gene Information
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Description : | This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. |
Source : | E. Coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized 100 ug human ATGL in 100 ul of TBS ( 20 mM Tris, 50mM NaCl, pH8.0 ), Carry free. |
Molecular Mass : | 73 KD |
AA Sequence : | human ATGL (Met1-Leu504)1 MFPREKTWNI SFAGCGFLGV YYVGVASCLR EHAPFLVANA THIYGASAGA LTATALVTGV CLGEAGAKFI EVSKEARKRF LGPLHPSFNL VKIIRSFLLK VLPADSHEHA SGRLGISLTRVSDGENVIIS HFNSKDELIQ ANVCSGFIPV YCGLIPPSLQ GVRYVDGGIS DNLPLYELKN TITVSPFSGE SDICPQDSST NIHELRVTNT SIQFNLRNLY RLSKALFPPE PLVLREMCKQGYRDGLRFLQ RNGLLNRPNP LLALPPARPH GPEDKDQAVE SAQAEDYSQL PGEDHILEHL PARLNEALLE ACVEPTDLLT TLSNMLPVRL ATAMMVPYTL PLESALSFTI RLLEWLPDVPEDIRWMKEQT GSICQYLVMR AKRKLGRHLP SRLPEQVELR RVQSLPSVPL SCAAYREALP GWMRNNLSLG DALAKWEECQ RQLLLGLFCT NVAFPPEALR MRAPADPAPA PADPASPQHQLAGPAPLLST PAPEARPVIG ALGL 504 |
Purity : | >90% in SDS-PAGE gel |
Applications : | Biology; ELISA |
Storage : | Store lyophilized protein at -20 °C or -70 °C. Lyophilized protein is stable for up to 6 months from date of receipt at - 20 °C to -70 °C. Upon reconstitution, this protein can be stored at -20 °C for a few weeks or at -70 °C in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freezing / thawing cycles. |
Reconstitution : | Add 500 ul deionized water to the vial to prepare a working stock solution at 200 ug/mL . Allow to set at least 30 minutes at 4 °C, mix well. |
Gene Name : | PNPLA2 patatin-like phospholipase domain containing 2 [ Homo sapiens ] |
Official Symbol : | PNPLA2 |
Synonyms : | PNPLA2; patatin-like phospholipase domain containing 2; TGL; TTS2; PEDF-R; FP17548; TTS-2.2; DESNUTRIN; DKFZp667M109; 1110001C14Rik; triglyceride hydrolase; adipose triglyceride lipase; transport-secretion protein 2.2; pigment epithelium-derived factor; Patatin-like phospholipase domain-containing protein 2; EC 3.1.1.3; Adipose triglyceride lipase; Desnutrin; Transport-secretion protein 2; TTS2.2; Calcium-independent phospholipase A2; IPLA2-zeta; Pigment epithelium-derived factor |
Gene ID : | 57104 |
mRNA Refseq : | NM_020376 |
Protein Refseq : | NP_065109 |
MIM : | 609059 |
UniProt ID : | Q96AD5 |
Chromosome Location : | 11p15.5 |
Pathway : | Acyl chain remodeling of DAG and TAG; Acylglycerol degradation; Fatty Acid Beta Oxidation; Glycerolipid metabolism |
Function : | triglyceride lipase activity |
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PNPLA2-1333H | Recombinant Human PNPLA2 Protein, His-SUMO-tagged | +Inquiry |
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◆ Lysates | ||
PNPLA2-3069HCL | Recombinant Human PNPLA2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionPNPLA2 influences energy homeostasis in muscles, facilitating fatty acid oxidation for energy production.
Changes in PNPLA2 activity affect cardiovascular health, potentially influencing the development of atherosclerosis.
PNPLA2 regulates liver lipid metabolism, impacting the development of fatty liver disease.
Mutations in PNPLA2 can lead to lipid storage diseases by disrupting normal lipid metabolism.
PNPLA2 plays a significant role in obesity and metabolic syndrome, affecting lipid storage and energy balance.
PNPLA2 modulates inflammation and insulin sensitivity, influencing metabolic health and the risk of diabetes.
PNPLA2 is crucial for lipid metabolism, breaking down triglycerides in adipose tissue for energy use.
Customer Reviews (3)
Write a reviewQuick and precise protein expression, a valuable asset.
Exceptional protein purification, highly recommended for our research.
Dependable mass spectrometry analysis, enhances our proteomics research.
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