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Recombinant Human PNPLA2, His-tagged

Cat.No. : PNPLA2-322H
Product Overview : A DNA sequence encoding the human ATGL (Met1-Leu504) with 6 His tag on the N-Terminus was expressed in E. Coli. This protein was purified by Ni-NTA column.
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Description : This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
Source : E. Coli
Species : Human
Tag : His
Form : Lyophilized 100 ug human ATGL in 100 ul of TBS ( 20 mM Tris, 50mM NaCl, pH8.0 ), Carry free.
Molecular Mass : 73 KD
AA Sequence : human ATGL (Met1-Leu504)1 MFPREKTWNI SFAGCGFLGV YYVGVASCLR EHAPFLVANA THIYGASAGA LTATALVTGV CLGEAGAKFI EVSKEARKRF LGPLHPSFNL VKIIRSFLLK VLPADSHEHA SGRLGISLTRVSDGENVIIS HFNSKDELIQ ANVCSGFIPV YCGLIPPSLQ GVRYVDGGIS DNLPLYELKN TITVSPFSGE SDICPQDSST NIHELRVTNT SIQFNLRNLY RLSKALFPPE PLVLREMCKQGYRDGLRFLQ RNGLLNRPNP LLALPPARPH GPEDKDQAVE SAQAEDYSQL PGEDHILEHL PARLNEALLE ACVEPTDLLT TLSNMLPVRL ATAMMVPYTL PLESALSFTI RLLEWLPDVPEDIRWMKEQT GSICQYLVMR AKRKLGRHLP SRLPEQVELR RVQSLPSVPL SCAAYREALP GWMRNNLSLG DALAKWEECQ RQLLLGLFCT NVAFPPEALR MRAPADPAPA PADPASPQHQLAGPAPLLST PAPEARPVIG ALGL 504
Purity : >90% in SDS-PAGE gel
Applications : Biology; ELISA
Storage : Store lyophilized protein at -20 °C or -70 °C. Lyophilized protein is stable for up to 6 months from date of receipt at - 20 °C to -70 °C. Upon reconstitution, this protein can be stored at -20 °C for a few weeks or at -70 °C in a manual defrost freezer for long term storage (six months). Aliquot reconstituted protein to avoid repeated freezing / thawing cycles.
Reconstitution : Add 500 ul deionized water to the vial to prepare a working stock solution at 200 ug/mL . Allow to set at least 30 minutes at 4 °C, mix well.
Gene Name : PNPLA2 patatin-like phospholipase domain containing 2 [ Homo sapiens ]
Official Symbol : PNPLA2
Synonyms : PNPLA2; patatin-like phospholipase domain containing 2; TGL; TTS2; PEDF-R; FP17548; TTS-2.2; DESNUTRIN; DKFZp667M109; 1110001C14Rik; triglyceride hydrolase; adipose triglyceride lipase; transport-secretion protein 2.2; pigment epithelium-derived factor; Patatin-like phospholipase domain-containing protein 2; EC 3.1.1.3; Adipose triglyceride lipase; Desnutrin; Transport-secretion protein 2; TTS2.2; Calcium-independent phospholipase A2; IPLA2-zeta; Pigment epithelium-derived factor
Gene ID : 57104
mRNA Refseq : NM_020376
Protein Refseq : NP_065109
MIM : 609059
UniProt ID : Q96AD5
Chromosome Location : 11p15.5
Pathway : Acyl chain remodeling of DAG and TAG; Acylglycerol degradation; Fatty Acid Beta Oxidation; Glycerolipid metabolism
Function : triglyceride lipase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does PNPLA2 influence energy homeostasis and fatty acid oxidation in muscle tissues? 05/12/2022

PNPLA2 influences energy homeostasis in muscles, facilitating fatty acid oxidation for energy production.

How do alterations in PNPLA2 expression or activity affect cardiovascular health and the risk of atherosclerosis? 04/07/2022

Changes in PNPLA2 activity affect cardiovascular health, potentially influencing the development of atherosclerosis.

How does PNPLA2 contribute to the regulation of hepatic lipid metabolism and the development of fatty liver disease? 02/11/2022

PNPLA2 regulates liver lipid metabolism, impacting the development of fatty liver disease.

What is the impact of PNPLA2 mutations on the pathogenesis of lipid storage diseases? 08/31/2021

Mutations in PNPLA2 can lead to lipid storage diseases by disrupting normal lipid metabolism.

What role does PNPLA2 play in the development and progression of obesity and related metabolic disorders? 08/19/2021

PNPLA2 plays a significant role in obesity and metabolic syndrome, affecting lipid storage and energy balance.

What are the mechanisms by which PNPLA2 modulates inflammation and insulin sensitivity? 06/08/2018

PNPLA2 modulates inflammation and insulin sensitivity, influencing metabolic health and the risk of diabetes.

How does PNPLA2 regulate lipid metabolism and triglyceride hydrolysis in adipose tissue? 01/29/2018

PNPLA2 is crucial for lipid metabolism, breaking down triglycerides in adipose tissue for energy use.

Customer Reviews (3)

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Reviews
05/14/2020

    Quick and precise protein expression, a valuable asset.

    09/09/2019

      Exceptional protein purification, highly recommended for our research.

      03/01/2018

        Dependable mass spectrometry analysis, enhances our proteomics research.

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