"ENOPH1" Related Products

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Enolase-phosphatase E1

Cat. No.: CBCRY26
Background: Enolase-phosphatase E1 (MASA) is a bifunctional enzyme in the ubiquitous methionine salvage pathway that catalyzes the continuous reactions of 2,3-diketo-5-methylthio-1-phosphopentane to yield the aci-reductone metabolite using Mg2+ as cofactor. In this study, we have determined the crystal structure of MASA and its complex with a substrate analog to 1.7A resolution by multi-wavelength anomalous diffraction and molecular replacement techniques, respectively.
Protein Classification: Hydrolase
Structure Weight: 29316.11 Da
Polymer: 1
Molecule: E-1 Enzyme
Chain Length: 285 amino acids
PDB ID: 1ZS9
MMDB ID: 33918
Source: E.coli
Method: X-Ray Diffraction
Resolution: 1.7Å
Ligand Chemical Component: Selenomethionine
Reference: Wang, H., Pang, H., Bartlam, M., Rao, Z. (2005) Crystal Structure of Human E1 Enzyme and its Complex with a Substrate Analog Reveals the Mechanism of its Phosphatase/Enolase J.Mol.Biol. 348: 917-926
Gene Name: ENOPH1
Synonyms: DKFZp586M0524; E1; FLJ12594; MASA; MST145; E-1 enzyme; Enolase-phosphatase E1; MSTP145 protein; acireductone synthase; EC 3.1.3.77; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; MASA homolog
UniProt ID: Q9UHY7
Gene ID: 58478
Chromosome Location: 4q21.22
Function: magnesium ion binding; phosphor-glycolate phosphatase activity; acireductone synthase activity; metal ion binding; catalytic activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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