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Rho Guanine Nucleotide Exchange Factor 7

Cat. No.: CBCRY28
Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.
Protein Classification: Signaling Protein
Structure Weight: 15255.28 Da
Polymer: 1
Molecule: Rho guanine nucleotide exchange factor 7
Chain Length: 61 amino acids
PDB ID: 2ESW
MMDB ID: 38672
Source: E.coli
Method: X-Ray Diffraction
Resolution: 2.01Å
Ligand Chemical Component: Chloride ion; Mercury ion
Reference: Li, X., Liu, X., Sun, F., Gao, J., Zhou, H., Gao, G.F., Bartlam, M., Rao, Z. (2006) Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor Biochem. Biophys. Res. Commun. 339: 407-414
Gene Name: Arhgef7
Synonyms: PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142; Arhgef7; PAK-interacting exchange factor beta; OTTMUSP00000023238; Pak3 binding protein; Pak interacting exchange factor; Dkfzp761k1021; kiaa0412; p50; p50bp; p85; pak3; pixb
UniProt ID: Q6XPA5
Gene ID: 54126
Chromosome Location: 8 A1.1
Function: guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; protein binding

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