Rho Guanine Nucleotide Exchange Factor 7


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Rho Guanine Nucleotide Exchange Factor 7

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Cat. No. : CBCRY28
Background : Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.
Protein Classification : Signaling Protein
Structure Weight : 15255.28 Da
Polymer : 1
Molecule : Rho guanine nucleotide exchange factor 7
Chain Length : 61 amino acids
MMDB ID : 38672
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.01Å
Ligand Chemical Component : Chloride ion; Mercury ion
Reference : Li, X., Liu, X., Sun, F., Gao, J., Zhou, H., Gao, G.F., Bartlam, M., Rao, Z. (2006) Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor Biochem. Biophys. Res. Commun. 339: 407-414
Gene Name : Arhgef7
Synonyms : PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142; Arhgef7; PAK-interacting exchange factor beta; OTTMUSP00000023238; Pak3 binding protein; Pak interacting exchange factor; Dkfzp761k1021; kiaa0412; p50; p50bp; p85; pak3; pixb
UniProt ID : Q6XPA5
Gene ID : 54126
Chromosome Location : 8 A1.1
Function : guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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