Dynein Light Chain Dnlc2a


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Dynein Light Chain Dnlc2a

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Cat. No. : CBCRY31
Background : The human light chain of the motor protein dynein, Dnlc2A, is also a novel TGF-beta-signaling component, which is altered with high frequency in epithelial ovarian cancer. It is an important mediator of dynein and the development of cancer, owing to its ability to bind to the dynein intermediate light chain (DIC) IC74 and to regulate TGF-beta-dependent transcriptional events.
Protein Classification : Transport Protein
Structure Weight : 24324.71 Da
Polymer : 1
Molecule : Dynein light chain 2A, cytoplasmic
Chain Length : 106 amino acids
MMDB ID : 53434
Source : E.coli
Method : X-Ray Diffraction
Resolution : 2.10Å
Ligand Chemical Component : Cesium ion
Reference : Liu, J.-F., Wang, Z.-X., Wang, X.-Q., Tang, Q., An, X.-M., Gui, L.-L., Liang, D.-C. (2006) Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74 Biochem.Biophys.Res.Commun. 349: 1125-1129
Gene Name : DYNLRB1
Synonyms : BITH; BLP; DNCL2A; DNLC2A; ROBLD1; OTTHUMP00000030691; ROBL/LC7-like 1; Roadblock-1; bithoraxoid-like protein; cytoplasmic dynein light chain 2A; dynein, cytoplasmic, light polypeptide 2A; dynein-associated protein HKM23; dynein-associated protein Km23; roadblock domain containing 1
UniProt ID : Q9NP97
Gene ID : 83658
Chromosome Location : 20q11.21
Function : microtubule motor activity; protein binding

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