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Recombinant Human PPARD, Ligand Binding Domain, His-tagged

Cat. No.: PPARD-1088H
Description: Recombinant His tagged PPARβ-LBD is isolated from an E.coli strain that carries the coding sequence of the human PPARβ under the control of a T7 promoter. There is evidence that a group of closely related nuclear receptors, called Peroxisome Proliferator- activated Receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, atherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9-cis retinoic acid, RXR (Retinoid X Receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified:α,β (also calledδ) and γ. PPARα is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPAR is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. PPARβ is found in many tissues but the highest expression is in the gut, kidney and heart. PPARβ has received little attention, probably because of the lack of a connection with important clinical manifestations. However, recently PPARβ has been linked to colon cancer, among other functions. PPAR regulates the expression of acyl-CoA synthetase 2 in the brain, linking PPARβ to basic lipid metabolism. Moreover, it probably participates in embryo implantation and decidualization.
Source: E. coli.
Form: Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA.
Purity: > 95% by SDS-PAGE.
Application: PPARβ has been applied in DNA and protein-protein interactions assays.
Usage: For in vitro use only.
Storage: Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
Gene Name: PPARD peroxisome proliferator-activated receptor delta [ Homo sapiens ]
Synonyms: PPARD; peroxisome proliferator-activated receptor delta; FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB; MGC3931; PPAR-beta; peroxisome proliferative activated receptor, delta; OTTHUMP00000016256; OTTHUMP00000016257; nuclear hormone receptor 1; PPAR-delta; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2
Gene ID: 5467
mRNA Refseq: NM_006238
Protein Refseq: NP_006229
MIM: 600409
UniProt ID: Q03181
Chromosome Location: 6p21.2
Pathway: Acute myeloid leukemia; PPAR signaling pathway; Pathways in cancer; Wnt signaling pathway
Function: NF-kappaB binding; drug binding; linoleic acid binding; metal ion binding; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription activator activity; transcription factor activity; transcription repressor activity; zinc ion binding

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