"USF1" Related Products


Recombinant Human Upstream Transcription Factor 1, GST-tagged

Cat. No.: USF1-1203H
Description: Human Upstream Stimulatory Factor 1 (USF1) regulates the transcription of many genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia (FCHL) and type 2-diabetes on chromosome 1q22-23. The USF1 protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. It is a basic helix-loop-helix leucine zipper (b-HLH-ZIP) protein that shares a common DNA-binding specificity with the c-Myc oncoproteins.
Source: E. coli.
Form: Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
Purity: >95% by SDS-PAGE.
Activity: 5-50 ng are sufficient for DNA binding assays, 50-500 ng are required for in vitro transcription assays and 100 ng are required for protein-protein interaction assays.
Usage: For in vitro use only.
Storage: Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
Gene Name: USF1 upstream transcription factor 1 [ Homo sapiens ]
Synonyms: USF1; upstream transcription factor 1; UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11; OTTHUMP00000029691; OTTHUMP00000029693; USF; Major late transcription factor 1; upstream stimulatory factor 1
Gene ID: 7391
mRNA Refseq: NM_007122
Protein Refseq: NP_009053
MIM: 191523
UniProt ID: P22415
Chromosome Location: 1q22-q23
Function: RNA polymerase II transcription factor activity, enhancer binding; RNA polymerase II transcription factor activity, enhancer binding; bHLH transcription factor binding; double-stranded DNA binding; histone deacetylase binding; protein heterodimerization activity; protein homodimerization activity; protein homodimerization activity; protein kinase binding; sequence-specific DNA binding; transcription activator activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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