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Recombinant Human NAD(P)H Dehydrogenase, Quinone 1

Cat. No.: NQO1-377H
Product Overview: Recombinant Human NQO1 protein was expressed in E.coli and purified by using conventional chromatography techniques. MW = 33.0 kDa (294aa).
Description: NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This protein apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. NQO1 functions as an important part of cellular antioxidant defense by detoxifying quinines thus preventing the formation of reactive oxygen species. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD).
Source: E.coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV FIGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK
Form: Liquid. In 20mM Tris-HCL buffer (pH 8.0) containing 10% glycerol 1mM DTT.
Purity: > 95% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: NQO1 NAD(P)H dehydrogenase, quinone 1 [ Homo sapiens ]
Synonyms: NQO1; NAD(P)H dehydrogenase, quinone 1; DTD; QR1; DHQU; DIA4; NMOR1; NMORI; azoreductase; diaphorase-4; DT-diaphorase; dioxin-inducible 1; menadione reductase; quinone reductase 1; phylloquinone reductase; NAD(P)H:quinone oxireductase; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; diaphorase (NADH/NADPH) (cytochrome b-5 reductase); EC 1.6.5.2; Phylloquinone reductase; NAD(P)H:quinone oxidoreductase 1; NAD(P)H menadione oxidoreductase 1, dioxin-inducible; NAD(P)H dehydrogenase, quinone 1
Gene ID: 1728
mRNA Refseq: NM_000903
Protein Refseq: NP_000894
MIM: 125860
UniProt ID: P15559
Chromosome Location: 16q12-q22
Function: NAD(P)H dehydrogenase (quinone) activity; coenzyme binding; cytochrome-b5 reductase activity; electron carrier activity; oxidoreductase activity

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