"VSNL1" Related Products

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Recombinant Human Visinin-like 1

Cat. No.: VSNL1-1406H
Product Overview: Recombinant human Visinin-like protein-1 was expressed inE.coliand purified by using conventional chromatography. MW =22.1 kDa (191aa).
Description: Visinin-like protein-1, also known as VILIP-1, belongs to a family of neuronal calcium sensor proteins. VILIP-1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Also, it is expressed in pancreatic beta-cells. VILIP-1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription.
Source: E.coli.
Amino Acid Sequence: MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
Purity: > 95 % by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: VSNL1 visinin-like 1 [ Homo sapiens ]
Synonyms: VSNL1; visinin-like 1; HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1; OTTHUMP00000200482; OTTHUMP00000200483; hippocalcin-like protein 3; VLP-1; Hippocalcin-like protein 3; VISL1
Gene ID: 7447
mRNA Refseq: NM_003385
Protein Refseq: NP_003376
MIM: 600817
UniProt ID: P62760
Chromosome Location: 2p24.3
Function: calcium ion binding

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