Recombinant Human Visinin-like 1

• Cat.No.: VSNL1-1406H
• Product Overview: Recombinant human Visinin-like protein-1 was expressed inE.coliand purified by using conventional chromatography. MW =22.1 kDa (191aa).

Specification

• Cat. No.: VSNL1-1406H
• Description: Visinin-like protein-1, also known as VILIP-1, belongs to a family of neuronal calcium sensor proteins. VILIP-1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Also, it is expressed in pancreatic beta-cells. VILIP-1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription.
• Source: E.coli.
• Amino Acid Sequence: MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
• Purity: > 95 % by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: VSNL1 visinin-like 1 [ Homo sapiens ]
• Synonyms: VSNL1; visinin-like 1; HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1; OTTHUMP00000200482; OTTHUMP00000200483; hippocalcin-like protein 3; VLP-1; Hippocalcin-like protein 3; VISL1
• Gene ID: 7447
• mRNA Refseq: NM_003385
• Protein Refseq: NP_003376
• MIM: 600817
• UniProt ID: P62760
• Chromosome Location: 2p24.3
• Function: calcium ion binding