"NDUFS4" Related Products

Recombinant Human NDUFS4

Cat. No.: NDUFS4-367H
Product Overview: Recombinant Human NDUFS4 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 134 amino acids (43-175 a.a.) and having a molecular mass of 15.5 kDa. The NDUFS4 is purified by proprietary chromatographic techniques.
Description: NDUFS4 is a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), the primary multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I is involved in cellular ATP production, the main source of energy for numerous vital processes in living cells. NDUFS4 removes electrons from NADH and passes them by a series of diverse protein-coupled redox centers to the electron acceptor ubiquinone. NDUFS4 presents a hotspot of mutations in the genetic apparatus of oxidative phosphorylation and the correct assembly of the subunit it encodes is essential for completion of the assembly of complex I.
Source: Escherichia Coli.
Amino Acid Sequence: MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK.
Physical Appearance: Sterile Filtered colorless solution.
Formulation: The NDUFS4 solution contains 20mM Tris pH-8 & 30% glycerol.
Purity: Greater than 90.0% as determined by SDS-PAGE.
Stability: NDUFS4 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) [ Homo sapiens ]
Synonyms: NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 4; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; mitochondrial respiratory chain complex I (18-KD subunit); AQDQ
Gene ID: 4724
mRNA Refseq: NM_002495
Protein Refseq: NP_002486
MIM: 602694
UniProt ID: O43181
Chromosome Location: 5q11.1
Pathway: Alzheimer"s disease; Huntington"s disease; Metabolic pathways; Metabolic pathways; Parkinson"s disease; Diabetes pathways; Electron Transport Chain; Integration of energy metabolism
Function: NADH dehydrogenase (ubiquinone) activity; oxidoreductase activity, acting on NADH or NADPH

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