"DMPK" Related Products


Recombinant Human DMPK, GST-tagged, Active

Cat. No. : DMPK-295H
Product Overview : Recombinant full-length human DMPK was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=105 kDa.
Description : DMPK (or Myotonic Dystrophy Protein Kinase) is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. DMPK protein has a leucine-rich domain at the N-terminus, a serine/threonine kinase domain in the middle, and a hydrophobic region at the C-terminus. The N-terminus of DMPK plays an important role in DMPK kinase activity, and the C-terminus of DMPK determines the intracellular localization of the protein. Myotonic dystrophy type 1 is an autosomal dominant disease caused by a trinucleotide repeat-expansion, cytosine-thymine-guanine (CTG)n, in the 3" untranslated region of DMPK.
Source : Sf9 insect cellsusing baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : DMPK dystrophia myotonica-protein kinase [ Homo sapiens ]
Synonyms : DMPK; dystrophia myotonica-protein kinase; DM; DM1; DMK; MDPK; DM1PK; MT-PK; DM protein kinase; myotonic dystrophy protein kinase; thymopoietin homolog; myotonin protein kinase A; myotonic dystrophy associated protein kinase; EC
Gene ID : 1760
mRNA Refseq : NM_001081560
Protein Refseq : NP_001075029
MIM : 605377
UniProt ID : Q09013
Chromosome Location : 19q13.3
Function : ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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