Recombinant Human CSF1R, GST-tagged, Active

• Cat.No.: CSF1R-320H
• Product Overview: Recombinant human FMS (539-end) was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=76kDa.

Specification

• Cat. No.: CSF1R-320H
• Description: FMS is a proto-oncogene that encodes the tyrosine kinase transmembrane receptor for colony stimulating factor 1 (CSF1). FMS is homodimeric that contains a so-called kinase insert domain and is a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. FMS mediates most if not all of the biological effects of CSF1 which control the production, differentiation, and function of cell of the monocyte/macrophage lineage. Mutations in FMS have been associated with providing sustained signals for cell growth and a predisposition to myeloid malignancy.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 593-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CSF1R colony stimulating factor 1 receptor [ Homo sapiens ]
• Synonyms: CSF1R; colony stimulating factor 1 receptor; C-FMS; CD115; CSFR; FIM2; FMS; CD115 antigen; FMS proto-oncogene; McDonough feline sarcoma viral (v-fms) oncogene homolog; macrophage colony stimulating factor I receptor; EC 2.7.10.1; soluble CSF1R variant 1
• Gene ID: 1436
• mRNA Refseq: NM_005211
• Protein Refseq: NP_005202
• UniProt ID: P07333
• Chromosome Location: 5q33-q35
• MIM: 164770
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Endocytosis; Pathways in cancer
• Function: ATP binding; cytokine binding; macrophage colony stimulating factor receptor activity; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity