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Recombinant Human CDK6/CCND1, His-tagged, GST-tagged, Active

Cat.No. : CDK6/CCND1-277H
Product Overview : Recombinant human full-length CDK6 and CyclinD1 were co-expressed by baculovirus inSf9insect cells using an N-terminal His tag on CDK6 and GST tag on CyclinD1 proteins. MW= 40kDa and CyclinD1 ~61kDa.
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  • Gene Information
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Cat. No. : CDK6/CCND1-277H
Description : CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors. The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the phosphorylation and regulation of the activity of tumor suppressor protein Rb. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CDK6 cyclin-dependent kinase 6 [ Homo sapiens ],CCND1 cyclin D1 [ Homo sapiens ]
Synonyms : CDK6; cyclin-dependent kinase 6; PLSTIRE; MGC59692;Cell division protein kinase 6;EC2.7.11.22; Serine/threonine-protein kinase; CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene
Gene ID : 1021,595
mRNA Refseq : NM_001145306,NM_053056
Protein Refseq : NP_001138778,NP_444284
UniProt ID : Q00534, P24385
Chromosome Location : 7q21-q22,11q13
MIM : 603368,168461
Pathway : Cell cycle; Chronic myeloid leukemia; Glioma; Melanoma; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Small cell lung cancer; p53 signaling pathway; Cell Cycle, Mitotic;Acute myeloid leukemia; Bladder cancer; Colorectal cancer; Endometrial cancer
Function : ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; cyclin binding; transferase activity;protein complex binding; protein kinase binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How is the expression level of CDK6 regulated? 10/02/2022

The expression level of CDK6 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation processes of the CDK6 gene, thereby regulating its expression level in cells.

What are the challenges in the development of CDK6 inhibitors? 02/08/2022

There are several challenges in the development of CDK6 inhibitors, including issues such as inhibitor selectivity, drug resistance, and drug delivery. In addition, since CDK6 also has a certain function in normal cells, the side effects of inhibitors are also a factor to consider.

Does CDK6 have a role in stem cell biology? 11/03/2021

It plays an important role in stem cell biology. It is involved in the process of self-renewal and differentiation of stem cells, as well as in determining the fate of stem cells. By regulating the activity of CDK6, it is possible to influence the proliferation and fate selection of stem cells.

What are the clinical applications of CDK6 inhibitors? 02/08/2021

CDK6 inhibitors have been developed as potential anti-cancer drugs and have shown some efficacy in clinical trials. They block the progression of the cell cycle by inhibiting the activity of CDK6, thereby inhibiting the proliferation of cancer cells.

How is CDK6 activity regulated? 02/24/2020

The activity of CDK6 is regulated at multiple levels, including binding to other cyclins and inhibitors, phosphorylation and dephosphorylation events, and transcriptional and post-translational modifications.

Does CDK6 function differently in different types of cancer? 01/14/2020

The role of CDK6 in different types of cancer may vary. It may act as a promoter in some cancers and as a suppressant in others. This difference can be related to factors such as the type, stage, and genetic background of the cancer.

Customer Reviews (3)

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Reviews
07/06/2023

    The results obtained after analysis by SDS-PAGE or Western blot were good.

    03/14/2022

      It has a wide range of applications and can be used in various biological experiments.

      10/26/2020

        The purity of CDK6 is good, and the experimental results obtained are very accurate.

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