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Recombinant Human Aurora Kinase A, GST-tagged, Active

Cat.No. : AURKA-246H
Product Overview : Recombinant full-length human AURORA A was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW = 72kDa.
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Cat. No. : AURKA-246H
Description : AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : AURKA aurora kinase A [ Homo sapiens ]
Synonyms : AURKA ; aurora kinase A; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; MGC34538; OTTHUMP00000031344; OTTHUMP00000166071; IPL1-related kinase; aurora-related kinase 1; aurora/IPL1-like kinase; serine/threonine kinase 6; breast-tumor-amplified kinase; serine/threonine protein kinase 15; EC 2.7.11.1; AurA; Aurora kinase A; Aurora-A; Serine/threonine kinase 15; hARK1; Breast tumor-amplified kinase; OTTHUMP00000031340; OTTHUMP00000031342; OTTHUMP00000031343; OTTHUMP00000031345; Breast tumor-amplified kinase 3; serine/threonine protein kinase 6
Gene ID : 6790
mRNA Refseq : NM_003600
Protein Refseq : NP_003591
MIM : 603072
UniProt ID : O14965
Chromosome Location : 20q13
Pathway : Cell Cycle, Mitotic
Function : ATP binding; nucleotide binding; protein binding; protein binding; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How does AURKA interact with cell cycle regulators? 07/19/2022

AURKA protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, Plk1, TPX2, etc., to regulate the progression of cell cycle.

What is the role of AURKA protein in the cell cycle? 09/26/2020

The protein plays an important role in the G2 and M phases of the cell cycle and is involved in the regulation of nuclear division, chromosome segregation, and cell mitosis.

Is AURKA protein involved in apoptosis and DNA damage repair? 09/09/2020

AURKA protein may be involved in the regulation of apoptosis and DNA damage repair, but the specific mechanism needs to be further studied.

What is the regulatory mechanism of AURKA protein activity? 01/02/2020

The activity is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

Where are the cells of AURKA protein? 10/06/2019

It is mainly localized in the cytoplasm and nucleus and is involved in cell cycle regulation and cell division processes.

What is the role of AURKA protein in tumorigenesis? 01/01/2019

This protein plays an important role in tumorigenesis, and its overexpression or mutation may lead to abnormal cell proliferation, chromosome instability and tumorigenesis.

Customer Reviews (3)

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Reviews
12/08/2022

    AURKA's exceptional stability allows for its reliable use in a range of applications, making it a top choice for researchers.

    02/10/2022

      This protein's exceptional activity allows for its reliable use in a range of applications, making it a top choice for researchers.

      10/24/2020

        Due to the extensive storage conditions of proteins, the experimental process is more stable and reliable, which provides a strong guarantee for scientific research.

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