"AURKA" Related Products

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Recombinant Human Aurora Kinase A, GST-tagged, Active

Cat. No.: AURKA-246H
Product Overview: Recombinant full-length human AURORA A was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW = 72kDa.
Description: AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: AURKA aurora kinase A [ Homo sapiens ]
Synonyms: AURKA ; aurora kinase A; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; MGC34538; OTTHUMP00000031344; OTTHUMP00000166071; IPL1-related kinase; aurora-related kinase 1; aurora/IPL1-like kinase; serine/threonine kinase 6; breast-tumor-amplified kinase; serine/threonine protein kinase 15; EC 2.7.11.1; AurA; Aurora kinase A; Aurora-A; Serine/threonine kinase 15; hARK1; Breast tumor-amplified kinase; OTTHUMP00000031340; OTTHUMP00000031342; OTTHUMP00000031343; OTTHUMP00000031345; Breast tumor-amplified kinase 3; serine/threonine protein kinase 6
Gene ID: 6790
mRNA Refseq: NM_003600
Protein Refseq: NP_003591
MIM: 603072
UniProt ID: O14965
Chromosome Location: 20q13
Pathway: Cell Cycle, Mitotic
Function: ATP binding; nucleotide binding; protein binding; protein binding; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding

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