Recombinant Human AMPK (A1/B2/G1), His-tagged, Active
Cat.No. : | AMPK(A1/B2/G1)-244H |
Product Overview : | Recombinant full-length human AMPK (combination of A1/B2/G1 subunits) was expressed by baculovirus inSf9 insect cellsusing a C-terminal His tags. MW = 68kDa (A1), 36kDa (B2), 40kDa (G1). |
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Cat. No. : | AMPK (A1/B2/G1)-244H |
Description : | AMPK (A1/B2/G1) is a member of the AMPK family which are heterotrimeric proteins consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress. AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and hydroxy beta-methylglutaryl-CoA reductase. The subunit may be a positive regulator of AMPK activity and is highly expressed in skeletal muscle. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Publication : |
AMPK regulates autophagy by phosphorylating BECN1 at threonine 388 (2016)
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Gene Name : | PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit [ Homo sapiens ],PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit [ Homo sapiens ],PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit [ Homo sapiens ] |
Synonyms : | protein kinase, AMP-activated, alpha 1 catalytic subunit; AMPK; AMPKa1; MGC33776; MGC57364; PRKAA1; AMPK alpha 1; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; 5""-AMP-activated protein kinase, catalytic alpha-1 chain; AMPK1EC; 2.7.11.1; AMPK alpha-1 chain, protein kinase, protein kinase, AMP-activated, beta 2 non-catalytic subunit; MGC61468; PRKAB2 ; AMP-activated protein kinase beta 2 non-catalytic subunit ; AMPK beta 2 ; AMPK beta-2 chain ; 5""-AMP-activated protein kinase, beta-2 subunit ; OTTHUMP00000015910; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; AMPKG; MGC8666; PRKAG1; AMPK gamma-1 chain; 5""-AMP-activated protein kinase, gamma-1 subunit; AMPKg; protein kinase, AMP-activated, gamma 1 non-catalytic subunit |
Gene ID : | 5562,5565,5571 |
mRNA Refseq : | NM_006251,NM_005399,NM_002733 |
Protein Refseq : | NP_006242,NP_005390,NP_002724 |
MIM : | 602739,602741,602742 |
UniProt ID : | Q13131, O43741, P54619 |
Chromosome Location : | 5p12, 1q21.1, 12q12-q14 |
Pathway : | Adipocytokine signaling pathway; Hypertrophic cardiomyopathy (HCM); Insulin signaling pathway; Regulation of autophagy; mTOR signaling pathway, Adipocytokine signaling pathway; Hypertrophic cardiomyopathy (HCM); Insulin signaling pathway, Adipocytokine signaling pathway; Hypertrophic cardiomyopathy (HCM); Insulin signaling pathway |
Function : | ATP binding; cAMP-dependent protein kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity, protein binding; protein kinase binding, AMP binding; AMP-activated protein kinase activity; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase regulator activity; protein binding; protein kinase binding |
Products Types
◆ Recombinant Protein | ||
PRKAA1-147H | Recombinant Human PRKAA1 Protein, His-tagged | +Inquiry |
PRKAA1-4327R | Recombinant Rat PRKAA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PRKAA1-01H | Recombinant Human PRKAA1 Protein (K45R) | +Inquiry |
PRKAA1-06H | Recombinant Human PRKAA1 complex Protein, N-Flag-tagged | +Inquiry |
PRKAA1-1762H | Recombinant Human PRKAA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PRKAA1-1412HCL | Recombinant Human PRKAA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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