Recombinant Human AMPK (A1/B1/G3), His-tagged, Active
| Cat.No. : | AMPK(A1/B1/G3)-243H |
| Product Overview : | Recombinant full-length human AMPK (combination of A1/B1/G3 subunits) was expressed by baculovirus inSf9 insect cellsusing a C-terminal His tags. MW = 68kDa (A1), 38kDa (B1), 51kDa (G3). |
- Specification
- Gene Information
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| Cat. No. : | AMPK (A1/B1/G3)-243H |
| Description : | AMPK (A1/B1/G3) is a member of the AMPK family which are heterotrimeric proteins consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress. AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and hydroxy beta-methylglutaryl-CoA reductase. The γ subunit is dominantly expressed in skeletal muscle where it may play a key role in the regulation of energy metabolism. |
| Source : | Sf9 insect cells using baculovirus. |
| Sequence : | Full-length. |
| Applications : | Kinase Assay, Western Blot. |
| Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : | PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit [ Homo sapiens ],PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit [ Homo sapiens ],PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit [ Homo sapiens ] |
| Synonyms : | protein kinase, AMP-activated, alpha 1 catalytic subunit; AMPK; AMPKa1; MGC33776; MGC57364; PRKAA1; AMPK alpha 1; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase, catalytic, alpha-1; 5"-AMP-activated protein kinase, catalytic alpha-1 chain; AMPK1EC; 2.7.11.1; AMPK alpha-1 chain, protein kinase, AMP-activated, beta 1 non-catalytic subunit; AMPK; HAMPKb; MGC17785; PRKAB1; AMPK beta 1; AMPK beta -1 chain; AMP-activated protein kinase beta subunit; 5"-AMP-activated protein kinase beta-1 subunit; protein kinase, AMP-activated, noncatalytic, beta-1; AMPKb; protein kinase, AMP-activated, beta 1 non-catalytic subunit, protein kinase, AMP-activated, gamma 3 non-catalytic subunit; AMPKG3; PRKAG3; AMP-activated protein kinase, non-catalytic gamma-3 subunit; AMPK gamma-3 chain; 5"-AMP-activated protein kinase, gamma-3 subunit; OTTHUMP00000164095; AMPK gamma3 |
| Gene ID : | 5562,5564,53632 |
| mRNA Refseq : | NM_006251,NM_006253,NM_017431 |
| Protein Refseq : | NP_006242,NP_006244,NP_059127 |
| MIM : | 602739,602740,604976 |
| UniProt ID : | Q13131, Q9Y478, Q9UGI9 |
| Chromosome Location : | 5p12, 12q24.1, 2q35 |
| Pathway : | Adipocytokine signaling pathway; Hypertrophic cardiomyopathy (HCM); Insulin signaling pathway; Regulation of autophagy; mTOR signaling pathway, Adipocytokine signaling pathway; Hypertrophic cardiomyopathy (HCM); Insulin signaling pathway, Adipocytokine signaling pathway; Hypertrophic cardiomyopathy (HCM); Insulin signaling pathway |
| Function : | ATP binding; cAMP-dependent protein kinase activity; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity, protein binding; protein kinase binding, AMP-activated protein kinase activity; protein kinase binding |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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