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Recombinant Human MARK3, GST-tagged, Active

Cat.No. : MARK3-349H
Product Overview : Recombinant full-length human MARK3 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 110 kDa.
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  • Gene Information
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Cat. No. : MARK3-349H
Description : Microtubule affinity-regulating kinase 3 (MARK3) is a member of the PAR-1/MARK kinase family which play critical roles in polarity and cell cycle control and are regulated by 14-3-3 scaffolding proteins, as well as the LKB1 tumour suppressor kinase and atypical protein kinase C (PKC). MARK3 is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating CDC2. MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MARK3 MAP/microtubule affinity-regulating kinase 3 [ Homo sapiens ]
Synonyms : MARK3; MAP/microtubule affinity-regulating kinase 3; KP78; CTAK1; PAR1A; EC 2.7.11.1; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Serine/threonine-protein kinase p78
Gene ID : 4140
mRNA Refseq : NM_001128918
Protein Refseq : NP_001122390
MIM : 602678
UniProt ID : P27448
Chromosome Location : 14q32.3
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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