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Recombinant Human MARK3, GST-tagged, Active

Cat. No.: MARK3-349H
Product Overview: Recombinant full-length human MARK3 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 110 kDa.
Description: Microtubule affinity-regulating kinase 3 (MARK3) is a member of the PAR-1/MARK kinase family which play critical roles in polarity and cell cycle control and are regulated by 14-3-3 scaffolding proteins, as well as the LKB1 tumour suppressor kinase and atypical protein kinase C (PKC). MARK3 is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating CDC2. MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: MARK3 MAP/microtubule affinity-regulating kinase 3 [ Homo sapiens ]
Synonyms: MARK3; MAP/microtubule affinity-regulating kinase 3; KP78; CTAK1; PAR1A; EC 2.7.11.1; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Serine/threonine-protein kinase p78
Gene ID: 4140
mRNA Refseq: NM_001128918
Protein Refseq: NP_001122390
MIM: 602678
UniProt ID: P27448
Chromosome Location: 14q32.3
Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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