"MET" Related Products

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Recombinant Human MET, GST-tagged, Active

Cat. No.: MET-353H
Product Overview: Recombinant human MET (956-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 81 kDa.
Description: MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovariancancers and has been shown to be involved in tumor cell migration and invasion.
Source: Sf9 insect cells using baculovirus.
Sequence: 956-end.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: MET met proto-oncogene (hepatocyte growth factor receptor) [ Homo sapiens ]
Synonyms: MET; met proto-oncogene (hepatocyte growth factor receptor); AUTS9; HGFR; RCCP2; c-Met; HGF receptor; OTTHUMP00000069168; SF receptor; met proto-oncogene; met proto-oncogene tyrosine kinase; oncogene MET; scatter factor receptor; EC 2.7.10.1; HGF/SF receptor; met proto-oncogene
Gene ID: 4233
mRNA Refseq: NM_000245
Protein Refseq: NP_000236
MIM: 164860
UniProt ID: P00533
Chromosome Location: 7q31
Pathway: Adherens junction; Axon guidance; Colorectal cancer; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Focal adhesion; Melanoma; Renal cell carcinoma
Function: Cell proliferation; cell surface receptor linked signal transduction; multicelllular organismal development; protein amino acid phosphorylation

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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