Recombinant Human MET, GST-tagged, Active

• Cat.No.: MET-353H
• Product Overview: Recombinant human MET (956-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 81 kDa.

Specification

• Cat. No.: MET-353H
• Description: MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovariancancers and has been shown to be involved in tumor cell migration and invasion.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 956-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MET met proto-oncogene (hepatocyte growth factor receptor) [ Homo sapiens ]
• Synonyms: MET; met proto-oncogene (hepatocyte growth factor receptor); AUTS9; HGFR; RCCP2; c-Met; HGF receptor; OTTHUMP00000069168; SF receptor; met proto-oncogene; met proto-oncogene tyrosine kinase; oncogene MET; scatter factor receptor; EC 2.7.10.1; HGF/SF receptor; met proto-oncogene
• Gene ID: 4233
• mRNA Refseq: NM_000245
• Protein Refseq: NP_000236
• MIM: 164860
• UniProt ID: P00533
• Chromosome Location: 7q31
• Pathway: Adherens junction; Axon guidance; Colorectal cancer; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Focal adhesion; Melanoma; Renal cell carcinoma
• Function: Cell proliferation; cell surface receptor linked signal transduction; multicelllular organismal development; protein amino acid phosphorylation