Recombinant Human MKNK2, GST-tagged, Active

• Cat.No.: MKNK2-356H
• Product Overview: Recombinant full-length human MNK2 was expressed by baculovirus inSf9insect cells using a N-terminal GST tag. MW = 74 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: MNK2 (MAP kinase-interacting kinase 2) contains a conserved C-terminal ERK-interacting domain, a catalytic domain with homology to the calcium/calmodulin-dependent family of kinases, and putative MAP kinase phosphorylation sites located within the T loop of the kinase domain. MNK2 binds tightly to the growth factor-regulated MAP kinases, ERK1 and ERK2. ERK and p38 phosphorylate MNK2, which stimulates its in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). A yeast two-hybrid screen showed the Mnk2 protein interacted with the ligand-binding domain of estrogen receptor beta (ERbeta).
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MKNK2 MAP kinase interacting serine/threonine kinase 2 [ Homo sapiens ]
• Synonyms: MKNK2; MAP kinase interacting serine/threonine kinase 2; MNK2; GPRK7; MAP kinase-interacting serine/threonine kinase 2; G protein-coupled receptor kinase 7; Putative map kinase interacting kinase; EC 2.7.11.1; MAP kinase signal-integrating kinase 2; Mnk2
• Gene ID: 2872
• mRNA Refseq: NM_017572
• Protein Refseq: NP_060042
• MIM: 5069
• UniProt ID: Q9HBH9
• Chromosome Location: 19p13.3
• Pathway: Insulin signaling pathway; MAPK signaling pathway
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity; zinc ion binding