"PAK6" Related Products

Recombinant Human PAK6, GST-tagged, Active

Cat. No.: PAK6-381H
Product Overview: Recombinant full-length human PAK6 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=110 kDa.
Description: PAK6 is a Ser/Thr protein kinase that is a member of the PAK (p21-activated kinase) family that are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 is highly expressed in the testis and prostate tissues and interacts with the androgen receptor (AR). In response to androgen, PAK6 cotranslocate into the nucleus with AR. PAK6 is weakly expressed in normal prostate epithelium but the expression is increased in primary and metastatic prostate cancer cells and is further increased in tumors that relapse after androgen deprivation therapy.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 [ Homo sapiens ]
Synonyms: PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; PAK5; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6; EC 2.7.11.1
Gene ID: 56924
mRNA Refseq: NM_001128628
Protein Refseq: NP_001122100
MIM: 608110
UniProt ID: Q9NQU5
Chromosome Location: 15q14
Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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