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Recombinant Human Protein Kinase C, Eta, GST-tagged, Active

Cat.No. : PRKCH-403H
Product Overview : Recombinant human full-length PKCeta was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=103 kDa.
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Cat. No. : PRKCH-403H
Description : PKCη is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCη is predominantly expressed in squamous cell epithelia and induces terminal differentiation of keratinocytes. PKCη that is endogenously expressed or overexpressed is found to associate with the cyclin E/cdk2/p21 complex in keratinocytes of mice and humans.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PRKCH protein kinase C, eta [ Homo sapiens ]
Synonyms : PRKCH; protein kinase C, eta; PKCL; PKC-L; PRKCL; MGC5363; MGC26269; nPKC-eta; Protein kinase C eta type; EC 2.7.11.13
Gene ID : 5583
mRNA Refseq : NM_006255
Protein Refseq : NP_006246
UniProt ID : P24723
Chromosome Location : 14q23.1
MIM : 605437
Pathway : Tight junction; Vascular smooth muscle contraction
Function : ATP binding; protein kinase C activity; enzyme binding; metal ion binding; nucleotide binding; transferase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials targeting PRKCH for therapeutic interventions? 11/19/2022

Yes, there are ongoing clinical trials exploring the potential of PRKCH as a therapeutic target in various diseases, including cancer and autoimmune disorders.

Is PRKCH protein involved in cardiovascular diseases, and how might it be targeted for therapeutic interventions? 10/27/2022

Yes, PRKCH has been implicated in cardiovascular diseases, and research is ongoing to explore its potential as a therapeutic target for conditions like hypertension and atherosclerosis.

Can PRKCH protein be a biomarker for certain diseases? 06/22/2019

Some studies suggest that altered levels of PRKCH could serve as a biomarker for certain diseases, aiding in early diagnosis and prognosis.

Are there any known genetic variations in the PRKCH gene associated with disease susceptibility? 06/09/2019

Genetic variations in the PRKCH gene have been investigated for their association with diseases, including autoimmune disorders and certain cancers.

In which clinical conditions is the expression of PRKCH protein dysregulated? 12/21/2018

Dysregulation of PRKCH has been observed in conditions such as autoimmune diseases, neurodegenerative disorders, and cardiovascular diseases.

Customer Reviews (3)

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Reviews
01/30/2023

    The high-quality PRKCH protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.

    11/18/2022

      PRKCH protein demonstrates great utility in protein electron microscopy structure analysis.

      04/03/2016

        In WB experiments, PRKCH protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.

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