Recombinant Human DSTYK, GST-tagged, Active

• Cat.No.: DSTYK-419H
• Product Overview: Recombinant full-length human DSTYK was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=140kDa.

Specification

• Cat. No.: DSTYK-419H
• Description: RIPK5 is a dual specificity serine/threonine and tyrosine protein kinase that is a member of the RIPK family. RIPK5 is widely expressed in vertebrates with broad distributed in the central nervous system, and deregulated in certain human cancers. RIPK5 has been shown to function as a regulator of cell death. Overexpression of RIPK5 leads to cell death as evidenced by DNA fragmentation. RIPK5 induces both caspase-dependent and caspase-independent cell death, and N- and C-terminal RIPK5 deletion mutants retained the ability to induce cell death.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: DSTYK dual serine/threonine and tyrosine protein kinase [ Homo sapiens ]
• Synonyms: DSTYK; dual serine/threonine and tyrosine protein kinase; RIP5; RIPK5; DustyPK; HDCMD38P; KIAA0472; dusty protein kinase; receptor interacting protein 5; EC 2.7.12.1
• Gene ID: 25778
• mRNA Refseq: NM_015375
• Protein Refseq: NP_056190
• MIM: 612666
• UniProt ID: Q6XUX3
• Chromosome Location: 1q32.1
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity; protein tyrosine kinase activity