|Cat. No. :
|Product Overview :
||Recombinant full-length human RPS6KA3 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=112kDa.
||RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression. Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations.
||Sf9 insect cells using baculovirus.
||Kinase Assay, Western Blot.
|Storage And Stability :
||Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
||Long-term potentiation; MAPK signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; mTOR signaling pathway; Signalling by NGF