"SLK" Related Products

Recombinant Human STE20-like Kinase (Yeast), GST-tagged, Active

Cat. No. : SLK-432H
Product Overview : Recombinant full-length human SLK was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 180 kDa.
Description : SLK or LOSK is a Ste20-like protein kinase that associates with microtubule and centrosome. Inhibition of SLK activity by dominant-negative mutant or RNAi leads to unfocused microtubule arrangement indicating that SLK is needed for microtubule organization and for the proper localization of Golgi complex. Expression of v-Src can down-regulate SLK activity through the involvement of CK2 which can directly phosphorylate and inhibit SLK activity whereas inhibition of CK2 in v-Src-transformed cells results in normal SLK activity. CK2 and SLK can be co-localized in fibroblasts spreading on fibronectin-coated substrates.
Source : Sf9 insect cells using baculovirus.
Sequence : Full length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : SLK STE20-like kinase (yeast) [ Homo sapiens ]
Synonyms : SLK; STE20-like kinase (yeast); LOSK; STK2; se20-9; KIAA0204; MGC133067; bA16H23.1; serine/threonine kinase 2; Long Ste20-like Kinase; CTCL tumor antigen se20-9; Ste20-related serine/threonine kinase; SNF1 sucrose nonfermenting like kinase; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase; EC; OTTHUMP00000020426; OTTHUMP00000059183; Hslk; STE20-like kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase; Serine/threonine-protein kinase 2; Ste20-related serine/threonine kinase; serine/threonine kinase 2
Gene ID : 9748
mRNA Refseq : NM_014720
Protein Refseq : NP_055535
UniProt ID : Q9H2G2
Chromosome Location : 10q24.33
Function : ATP binding; DNA binding; nuclease activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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