"SRPK2" Related Products

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Recombinant Human SFRS Protein Kinase 2, GST-tagged, Active

Cat. No.: SRPK2-436H
Product Overview: Recombinant full-length human SRPK2 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 135 kDa.
Description: SRPK2 is a member of the serine/arginine (SR) protein-specific kinase family that are cell cycle-regulated protein kinases which phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing events. SRPK2 knock down results in hypophosphorylation of the serine/arginine domain-containing human PRP28 protein thereby destabilizing PRP28 association with the tri-snRNP. RNAi-mediated depletion in HeLa cells showed that SRPK2 is essential for cell viability, and it is required for spliceosomal B complex formation.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: SRPK2 SFRS protein kinase 2 [ Homo sapiens ]
Synonyms: SRPK2; SFRS protein kinase 2; SFRSK2; FLJ36101; serine/arginine-rich protein-specific kinase 2; H_RG152G17.1a; H_RG152G17.1b; WUGSC:H_RG152G17.1a; serine kinase SRPK2; EC 2.7.11.1; SR-protein-specific kinase 2; Serine/threonine-protein kinase SRPK2
Gene ID: 6733
mRNA Refseq: NM_182691
Protein Refseq: NP_872633
MIM: 602980
UniProt ID: P78362
Chromosome Location: 7q22-q31.1
Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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