"PTPN12" Related Products


Recombinant Human PTPN12, GST-tagged, Active

Cat. No.: PTPN12-462H
Product Overview: Recombinant human PTPN12 (1-355) was expressed inE. colicells using a N-terminal GST tag. MW = 66 kDa.
Description: Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events.
Source: E. coli.
Sequence: 1-355.
Applications: Phosphatase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ]
Synonyms: protein tyrosine phosphatase, non-receptor type 12; PTPG1; PTP-PEST; PTPN12; protein-tyrosine phosphatase G1; tyrosine-protein phosphatase non-receptor type 12; EC; OTTHUMP00000025119; Protein-tyrosine phosphatase G1
Gene ID: 5782
mRNA Refseq: NM_001131008
Protein Refseq: NP_001124480
MIM: 600079
UniProt ID: Q05209
Chromosome Location: 7q11.23
Function: SH3 domain binding; hydrolase activity; protein binding; non-membrane spanning protein tyrosine phosphatase activity

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