"PTPRF" Related Products

Recombinant Human PTPRF, GST-tagged, Active

Cat. No. : PTPRF-469H
Product Overview : Recombinant human PTPRF (1275-1897) was expressed inE.Coliusing an N-terminal GST tag. MW=93kDa.
Description : PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Source : E.Coli.
Sequence : 1275-1897.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
22q13.33 : 1p34
PDB rendering based on 1lar. :

Gene Name : PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ]
Synonyms : PTPRF; protein tyrosine phosphatase, receptor type, F; LCA-homolog; OTTHUMP00000008683; OTTHUMP00000008684; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; LAR; FLJ43335; FLJ45062; FLJ45567; EC 3.1.3.48
Gene ID : 5792
mRNA Refseq : NM_002840
Protein Refseq : NP_002831
MIM : 179590
UniProt ID : P10586
Pathway : Adherens junction; Cell adhesion molecules (CAMs); Insulin signaling pathway
Function : heparan sulfate proteoglycan binding; heparin binding; hydrolase activit; protein binding; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity

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