Recombinant Human ACVRL1

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Recombinant Human ACVRL1

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Cat.No. : ACVRL1-26593TH
Product Overview : Recombinant human ACVRL1 fragment was expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 64kDa.
Description : This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Biological activity : The specific activity of ACVRL1-26593TH was determined to be 22 nmol /min/mg.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 GS domain.Contains 1 protein kinase domain.
Gene Name : ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ]
Official Symbol : ACVRL1
Synonyms : ACVRL1; activin A receptor type II-like 1; ACVRLK1, ORW2; serine/threonine-protein kinase receptor R3; ALK1; HHT; HHT2;
Gene ID : 94
mRNA Refseq : NM_000020
Protein Refseq : NP_000011
MIM : 601284
Uniprot ID : P37023
Chromosome Location : 12q11-q14
Pathway : ALK1 pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; Id Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function : ATP binding; SMAD binding; activin binding; activin receptor activity, type I; contributes_to activin receptor activity, type I;

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