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Recombinant Human AES, His-tagged

Cat.No.: AES-28533TH
Product Overview: Recombinant fragment: LQAQYHSLKL ECDKLASEKS EMQRHYVMYY EMSYGLNIEM HKQAEIVKRL NGICAQVLPY LSQEHQQQVL GAIERAKQVT APELNSIIRQ LQAHQLSQLQ ALALPLTPLP VGLQPPSLPA VSAGTGLLSL SALGSQAHLS KEDKNGHDGD THQEDDGEKS D, corresponding to amino acids 36-197 of Human GRG with
Description: The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
Protein length: 162 amino acids
Conjugation: HIS
Molecular Weight: 19.000kDa inclusive of tags
Source: E. coli
Tissue specificity: Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
Form: Lyophilised:Reconstitute with 157 μl aqua dest.
Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: LQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD
Sequence Similarities: Belongs to the WD repeat Groucho/TLE family.
Gene Name: AES amino-terminal enhancer of split [ Homo sapiens ]
Official Symbol: AES
Synonyms: AES; amino-terminal enhancer of split; GRG5; TLE5;
Gene ID: 166
mRNA Refseq: NM_001130
Protein Refseq: NP_001121
MIM: 600188
Uniprot ID: Q08117
Chromosome Location: 19p13.3
Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Presenilin action in Notch and Wnt signaling, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem;
Function: protein binding; transcription corepressor activity; transcription corepressor activity; transcription corepressor activity;

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