Recombinant Human AHSP
Cat.No. : | AHSP-26663TH |
Product Overview : | Recombinant full length Human Ahsp, amino acids 1-102, MWt 11.8 kDa. |
- Specification
- Gene Information
- Related Products
Description : | AHSP(Alpha-hemoglobin stabilizing protein), also known as ERAF(Erythroid associated factor), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of α-hemoglobin during normal erythroid cell development. |
Source : | E. coli |
Tissue specificity : | Expressed in blood and bone marrow. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS |
Sequence Similarities : | Belongs to the AHSP family. |
Gene Name : | AHSP alpha hemoglobin stabilizing protein [ Homo sapiens ] |
Official Symbol : | AHSP |
Synonyms : | AHSP; alpha hemoglobin stabilizing protein; ERAF, erythroid associated factor; alpha-hemoglobin-stabilizing protein; alpha hemoglobin stabilising protein; EDRF; |
Gene ID : | 51327 |
mRNA Refseq : | NM_016633 |
Protein Refseq : | NP_057717 |
MIM : | 605821 |
Uniprot ID : | Q9NZD4 |
Chromosome Location : | 16p11.1 |
Function : | hemoglobin binding; unfolded protein binding; |
Products Types
◆ Recombinant Protein | ||
AHSP-4866H | Recombinant Human AHSP protein, GST-tagged | +Inquiry |
Ahsp-616R | Recombinant Rat Ahsp Protein, His/GST-tagged | +Inquiry |
aHSP-3367H | Recombinant Human aHSP, His-tagged, S tagged | +Inquiry |
AHSP-614H | Recombinant Human AHSP Protein, His-tagged | +Inquiry |
Ahsp-615M | Recombinant Mouse Ahsp Protein, His-tagged | +Inquiry |
◆ Lysates | ||
AHSP-8959HCL | Recombinant Human AHSP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
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Q&As (10)
Ask a questionechniques such as isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) are commonly employed to quantify the binding affinity and kinetics of Ahsp-alpha-globin interactions.
Ahsp deficiency can lead to unstable alpha-globin chains, contributing to the development of certain hemoglobinopathies like alpha-thalassemia.
Ahsp expression may be upregulated during cellular stress to enhance its protective role in stabilizing alpha-globin chains and preventing protein aggregation.
Techniques such as nuclear magnetic resonance (NMR), X-ray crystallography, and molecular dynamics simulations are commonly used to study protein-protein interactions involving Ahsp and alpha-globin.
Ahsp can interact with molecular chaperones like Hsp70 to assist in protein folding and prevent misfolding of alpha-globin chains.
Ahsp binds to free alpha-globin chains, preventing their aggregation and degradation by maintaining their folded state.
Ahsp plays a role in preventing excess alpha-globin chains from aggregating and precipitating, which is a key factor in the pathogenesis of alpha-thalassemia.
Ahsp's role is unique, focusing specifically on stabilizing alpha-globin chains, whereas other chaperones have broader functions in assisting protein folding and transport.
Ahsp indirectly influences iron metabolism by stabilizing alpha-globin chains and preventing their degradation, which in turn maintains balanced globin chain production and minimizes iron waste.
Ahsp's role in stabilizing alpha-globin chains helps prevent the formation of toxic aggregates that could damage red blood cells and shorten their lifespan.
Customer Reviews (5)
Write a reviewOutstanding product supplement. Worth every penny and arrived ahead of schedule.
Top-notch lab protein for a fraction of the cost. Superb value for money.
Great protein quality at an affordable price. Impressed with the results!
Exceptional quality product that doesn't break the bank. Fast delivery too!
This protein product is a game-changer – premium quality and budget-friendly.
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