Recombinant Human AHSP Protein, His-tagged
Cat.No. : | AHSP-614H |
Product Overview : | Recombinant Human AHSP(Met1~Ser102) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 17.6kDa |
Identity : | Reconstitute in PBS or others |
Protein length : | Met1~Ser102 |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others |
Gene Name : | AHSP alpha hemoglobin stabilizing protein [ Homo sapiens ] |
Official Symbol : | AHSP |
Synonyms : | AHSP; alpha hemoglobin stabilizing protein; ERAF, erythroid associated factor; alpha-hemoglobin-stabilizing protein; alpha hemoglobin stabilising protein; EDRF; erythroid associated factor; erythroid-associated factor; erythroid differentiation-related factor; erythroid differentiation associated factor; ERAF; |
Gene ID : | 51327 |
mRNA Refseq : | NM_016633 |
Protein Refseq : | NP_057717 |
MIM : | 605821 |
UniProt ID : | Q9NZD4 |
Products Types
◆ Recombinant Protein | ||
aHSP-3367H | Recombinant Human aHSP, His-tagged, S tagged | +Inquiry |
Ahsp-616R | Recombinant Rat Ahsp Protein, His/GST-tagged | +Inquiry |
Ahsp-615M | Recombinant Mouse Ahsp Protein, His-tagged | +Inquiry |
AHSP-0103H | Recombinant Human AHSP Protein (Met1-Ser102), His-tagged | +Inquiry |
AHSP-4866H | Recombinant Human AHSP protein, GST-tagged | +Inquiry |
◆ Lysates | ||
AHSP-8959HCL | Recombinant Human AHSP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
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Q&As (10)
Ask a questionechniques such as isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) are commonly employed to quantify the binding affinity and kinetics of Ahsp-alpha-globin interactions.
Ahsp deficiency can lead to unstable alpha-globin chains, contributing to the development of certain hemoglobinopathies like alpha-thalassemia.
Ahsp expression may be upregulated during cellular stress to enhance its protective role in stabilizing alpha-globin chains and preventing protein aggregation.
Techniques such as nuclear magnetic resonance (NMR), X-ray crystallography, and molecular dynamics simulations are commonly used to study protein-protein interactions involving Ahsp and alpha-globin.
Ahsp can interact with molecular chaperones like Hsp70 to assist in protein folding and prevent misfolding of alpha-globin chains.
Ahsp binds to free alpha-globin chains, preventing their aggregation and degradation by maintaining their folded state.
Ahsp plays a role in preventing excess alpha-globin chains from aggregating and precipitating, which is a key factor in the pathogenesis of alpha-thalassemia.
Ahsp's role is unique, focusing specifically on stabilizing alpha-globin chains, whereas other chaperones have broader functions in assisting protein folding and transport.
Ahsp indirectly influences iron metabolism by stabilizing alpha-globin chains and preventing their degradation, which in turn maintains balanced globin chain production and minimizes iron waste.
Ahsp's role in stabilizing alpha-globin chains helps prevent the formation of toxic aggregates that could damage red blood cells and shorten their lifespan.
Customer Reviews (5)
Write a reviewOutstanding product supplement. Worth every penny and arrived ahead of schedule.
Top-notch lab protein for a fraction of the cost. Superb value for money.
Great protein quality at an affordable price. Impressed with the results!
Exceptional quality product that doesn't break the bank. Fast delivery too!
This protein product is a game-changer – premium quality and budget-friendly.
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