Recombinant Human ALDOA, His-tagged

• Cat.No.: ALDOA-26500TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-364 of Human Aldolase with an N-terminal His tag; Predicted MWt 40kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-364 a.a.
• Description: The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
• Conjugation: HIS
• Form: Lyophilised:Reconstitution with 71 μl aqua dest
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium hydrogen phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSI AKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVI LFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPL AGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKI GEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPD GDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPN MVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITF LSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQA SALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPS GQAGAAASESLFVSNHAY
• Full Length: Full L.

Gene Information

• Gene Name: ALDOA aldolase A, fructose-bisphosphate [ Homo sapiens ]
• Official Symbol: ALDOA
• Synonyms: ALDOA; aldolase A, fructose-bisphosphate; fructose-bisphosphate aldolase A
• Gene ID: 226
• mRNA Refseq: NM_000034
• Protein Refseq: NP_000025
• MIM: 103850
• Uniprot ID: P04075
• Chromosome Location: 16p11.2
• Pathway: Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Gluconeogenesis, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem
• Function: actin binding; cytoskeletal protein binding; fructose binding; fructose-bisphosphate aldolase activity; identical protein binding