"ANGPT1" Related Products

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Recombinant Human ANGPT1, FLAG-tagged

Cat.No.: ANGPT1-27317TH
Product Overview: Recombinant fragment corresponding to amino acids 20-498 of Human Angiopoietin 1 with an N terminual DDDDK tag; MWt 57 kDa .
Description: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Protein length: 479 amino acids
Conjugation: FLAG
Molecular Weight: 57.000kDa inclusive of tags
Source: E. coli
Biological activity: Induces phosphorylation of Tie-2 in primary cultured human vascular endothelial cells (HUVECs). Binds to Human Tie-2. The protein forms mainly tetrameric structures.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 0.02% CHAPS, PBS
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Contains 1 fibrinogen C-terminal domain.
Gene Name: ANGPT1 angiopoietin 1 [ Homo sapiens ]
Official Symbol: ANGPT1
Synonyms: ANGPT1; angiopoietin 1; angiopoietin-1; Ang1; KIAA0003;
Gene ID: 284
mRNA Refseq: NM_001146
Protein Refseq: NP_001137
MIM: 601667
Uniprot ID: Q15389
Chromosome Location: 8q23.1
Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function: receptor tyrosine kinase binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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