Recombinant Human ANXA2 Protein

• Cat.No.: ANXA2-26598TH
• Product Overview: Recombinant Human ANXA2 Protein (2-339 aa) without tag was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 2-339 aa
• Description: ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
• Form: Lyophilized from 0.22 μm filtered solution in PBS, 50 mM L-arginine, 4 mM DTT (pH 7.4).
• Molecular Mass: 39.6 kDa
• Endotoxin: Level Less than 1 EU/μg by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE
• Storage: Upon receiving, the product remains stable for 6 months at -20 centigrade or below. Upon reconstitution, the product should be stable for 3 months at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Gene Information

• Gene Name: ANXA2 annexin A2 [ Homo sapiens ]
• Official Symbol: ANXA2
• Synonyms: ANXA2; annexin A2; ANX2, ANX2L4, CAL1H, LPC2D; annexin II; LIP2; annexin-2; protein I; lipocortin II; chromobindin 8; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; calpactin I heavy polypeptide; placental anticoagulant protein IV; P36; ANX2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV
• Gene ID: 302
• mRNA Refseq: NM_001002857
• Protein Refseq: NP_001002857
• MIM: 151740
• UniProt ID: P07355