||Full length native Apolipoprotein B purified fromHuman Plasma, Low Density Lipoprotein, predicted MW 516 kDa.
||This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 50% Sodium chloride, 50mM Sodium carbonate, 10mM Sodium Deoxycholate, pH 10
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||Purified by column chromatography Single arc by IEP against whole Human serum.
||Contains 1 vitellogenin domain.