Native Human APOB

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Native Human APOB

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Cat.No. : APOB-26875TH
Product Overview : Full length native Apolipoprotein B purified fromHuman Plasma, Low Density Lipoprotein, predicted MW 516 kDa.
Description : This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Sodium chloride, 50mM Sodium carbonate, 10mM Sodium Deoxycholate, pH 10
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : Purified by column chromatography Single arc by IEP against whole Human serum.
Sequence Similarities : Contains 1 vitellogenin domain.
Gene Name : APOB apolipoprotein B (including Ag(x) antigen) [ Homo sapiens ]
Official Symbol : APOB
Synonyms : APOB; apolipoprotein B (including Ag(x) antigen); apolipoprotein B-100;
Gene ID : 338
mRNA Refseq : NM_000384
Protein Refseq : NP_000375
Uniprot ID : P04114
Chromosome Location : 2p24-p23
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem;
Function : cholesterol transporter activity; enzyme binding; heparin binding; lipid transporter activity; low-density lipoprotein particle receptor binding;

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