Recombinant Human APP

• Cat.No.: APP-27315TH
• Product Overview: Recombinant fragment: EVHHQKLVFFAEDVGSNKGAII, corresponding to amino acids 11-40 of Human Amyloid beta precursor protein, 3151.7 Daltons.

Specification

• Description: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
• Source: E. coli
• Tissue specificity: Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Mod
• Form: Lyophilised:Resuspend in 1% NH4OH to a concentration of 1 mg/mL. Sonicate for 30 seconds to 1 minute after the powder has gone into solution.After resuspension, add 5x or 10x buffer stock (PBS, TBS) and water to bring to 1x buffer.Upon reconstitution main
• Storage: Store at -20°C. Stable for 12 months at -20°C
• Sequences of amino acids: Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe- Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala- Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
• Sequence Similarities: Belongs to the APP family.Contains 1 BPTI/Kunitz inhibitor domain.

Gene Information

• Gene Name: APP amyloid beta (A4) precursor protein [ Homo sapiens ]
• Official Symbol: APP
• Synonyms: APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II
• Gene ID: 351
• mRNA Refseq: NM_000484
• Protein Refseq: NP_000475
• Uniprot ID: P05067
• Chromosome Location: 21q21.2
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyloids, organism-specific biosystem
• Function: DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding