"APPL2" Related Products

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Recombinant Human APPL2, His-tagged

Cat.No.: APPL2-28348TH
Product Overview: Recombinant full length mature Human DIP13B with N terminal His tag; amino acids 2-665 , 78.6kDa.
Description: The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
Conjugation: HIS
Source: E. coli
Form: Lyophilised:Add deionized water to prepare a working stock solution of approximately 1 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MSYYHHHHHH DYDIPTTENL YFQGAMGSGI QRPTSTPAVD KLLLEEALQD SPQTRSLLSV FEEDAGTLTD YTNQLLQAMQ RVYGAQNEMC LATQQLSKQL LAYEKQNFAL GKGDEEVIST LHYFSKVVDE LNLLHTELAK QLADTMVLPI IQFREKDLTE VSTLKDLFGL ASNEHDLSMA KYSRLPKKKE NEKVKTEVGK EVAAARRKQH LSSLQYYCAL NALQYRKQMA MMEPMIGFAH GQINFFKKGA EMFSKRMDSF LSSVADMVQS IQVELEAEAE KMRVSQQELL SVDESVYTPD SDVAAPQINR NLIQKAGYLN LRNKTGLVTT TWERLYFFTQ GGNLMCQPRG AVAGGLIQDL DNCSVMAVDC EDRRYCFQIT TPNGKSGIIL QAESRKENEE WICAINNISR QIYLTDNPEA VAIKLNQTAL QAVTPITSFG KKQESSCPSQ NLKNSEMENE NDKIVPKATA SLPEAEELIA PGTPIQFDIV LPATEFLDQN RGSRRTNPFG ETEDESFPEA EDSLLQQMFI VRFLGSMAVK TDSTTEVIYE AMRQVLAARA IHNIFRMTES HLMVTSQSLR LIDPQTQVSR ANFELTSVTQ FAAHQENKRL VGFVIRVPES TGEESLSTYI FESNSEGEKI CYAINLGKEI IEVQKDPEAL AQLMLSIPLT NDGKYVLLND QPDDDDGNPN EHRGAESEA
Gene Name: APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 [ Homo sapiens ]
Official Symbol: APPL2
Synonyms: APPL2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13B; FLJ10659;
Gene ID: 55198
mRNA Refseq: NM_018171
Protein Refseq: NP_060641
MIM: 606231
Uniprot ID: Q8NEU8
Chromosome Location: 12q24.1
Pathway: EGFR1 Signaling Pathway, organism-specific biosystem;
Function: protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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