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Recombinant Human AURKA, His-tagged

Cat.No. : AURKA-27420TH
Product Overview : Recombinant full length human Aurora A fused to His tag at N-terminus; amino acids 1-403 , 47.9kDa.
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  • Gene Information
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Description : The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
Conjugation : HIS
Source : E. coli
Tissue specificity : Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20mM Tris HCl, 100mM Sodium chloride, 0.5mM DTT, 0.1mM EGTA, 0.1mM EDTA, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRIPLQ AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKRISRVEFTFPD FVTEGARDLI SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS
Sequence Similarities : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain.
Gene Name : AURKA aurora kinase A [ Homo sapiens ]
Official Symbol : AURKA
Synonyms : AURKA; aurora kinase A; serine/threonine kinase 6 , serine/threonine kinase 15 , STK6, STK15; ARK1; AurA; BTAK; PPP1R47; protein phosphatase 1; regulatory subunit 47; STK7;
Gene ID : 6790
mRNA Refseq : NM_003600
Protein Refseq : NP_003591
MIM : 603072
Uniprot ID : O14965
Chromosome Location : 20q13
Pathway : APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem;
Function : ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How does AURKA interact with cell cycle regulators? 07/19/2022

AURKA protein interacts with a variety of cell cycle regulatory proteins, including Cdk1, Plk1, TPX2, etc., to regulate the progression of cell cycle.

What is the role of AURKA protein in the cell cycle? 09/26/2020

The protein plays an important role in the G2 and M phases of the cell cycle and is involved in the regulation of nuclear division, chromosome segregation, and cell mitosis.

Is AURKA protein involved in apoptosis and DNA damage repair? 09/09/2020

AURKA protein may be involved in the regulation of apoptosis and DNA damage repair, but the specific mechanism needs to be further studied.

What is the regulatory mechanism of AURKA protein activity? 01/02/2020

The activity is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

Where are the cells of AURKA protein? 10/06/2019

It is mainly localized in the cytoplasm and nucleus and is involved in cell cycle regulation and cell division processes.

What is the role of AURKA protein in tumorigenesis? 01/01/2019

This protein plays an important role in tumorigenesis, and its overexpression or mutation may lead to abnormal cell proliferation, chromosome instability and tumorigenesis.

Customer Reviews (3)

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Reviews
12/08/2022

    AURKA's exceptional stability allows for its reliable use in a range of applications, making it a top choice for researchers.

    02/10/2022

      This protein's exceptional activity allows for its reliable use in a range of applications, making it a top choice for researchers.

      10/24/2020

        Due to the extensive storage conditions of proteins, the experimental process is more stable and reliable, which provides a strong guarantee for scientific research.

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