Recombinant Human AURKB
Cat.No. : | AURKB-26601TH |
Product Overview : | Recombinant fusion protein, full length human Aurora B expressed by baculovirus in Sf9 insect cells using an N-terminal proprietary tag. |
- Specification
- Gene Information
- Related Products
Description : | Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al. |
Tissue specificity : | High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain. |
Gene Name : | AURKB aurora kinase B [ Homo sapiens ] |
Official Symbol : | AURKB |
Synonyms : | AURKB; aurora kinase B; serine/threonine kinase 12 , STK12; Aik2; AIM 1; ARK2; AurB; aurora 1; aurora B; IPL1; PPP1R48; protein phosphatase 1; regulatory subunit 48; STK5; |
Gene ID : | 9212 |
mRNA Refseq : | NM_004217 |
Protein Refseq : | NP_004208 |
MIM : | 604970 |
Uniprot ID : | Q96GD4 |
Chromosome Location : | 17p13.1 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Aurora C signaling, organism-specific biosystem; |
Function : | ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
AURKB-909M | Recombinant Mouse AURKB Protein, His (Fc)-Avi-tagged | +Inquiry |
AURKB-1112H | Recombinant Human AURKB Protein (A2-A344), Tag Free | +Inquiry |
AURKB-560R | Recombinant Rat AURKB Protein, His (Fc)-Avi-tagged | +Inquiry |
Aurkb-279R | Recombinant Rat Aurkb Protein, His-tagged | +Inquiry |
AURKB-05H | Recombinant Human AURKB (D200A) Mutant Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
AURKB-8560HCL | Recombinant Human AURKB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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