Recombinant Human BACE1, FLAG-tagged BACE1-27426TH

Recombinant Human BACE1, FLAG-tagged

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Recombinant Human BACE1, FLAG-tagged

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Cat.No. : BACE1-27426TH
Product Overview : RecombinantBACE1 protein (Human), with a C-terminal DYKDDDDK-tag, extracellular domain.Expressed in HEK-293 cells
Description : Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
Conjugation : FLAG
Tissue specificity : Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Biological activity : Specific Activity: >10,000 units per mg protein.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20mM HEPES, 125mM Sodium chloride, pH 7.4
Storage : Store at +4°C.
Sequence Similarities : Belongs to the peptidase A1 family.
Gene Name : BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ]
Official Symbol : BACE1
Synonyms : BACE1; beta-site APP-cleaving enzyme 1; BACE, beta site APP cleaving enzyme; beta-secretase 1;
Gene ID : 23621
mRNA Refseq : NM_001207048
Protein Refseq : NP_001193977
MIM : 604252
Uniprot ID : P56817
Chromosome Location : 11q23-q24
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
Function : aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity;

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