Expand| Cat. No. : | CTNNB1-1441H |
| Product Overview : | Recombinant full-length human Catenin beta was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 115kDa. |
| Description : | β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. β-catenin interacts with TCF and LEF transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3β, form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of β-catenin by the proteasome. APC and Siah-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas. |
| Source : | Sf9 insect cells using baculovirus. |
| Sequence : | Full-length. |
| Applications : | Western Blot. |
| Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Gene Name : | CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [ Homo sapiens ] |
| Synonyms : | CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; beta-catenin; Catenin beta-1; Beta-catenin |
| Gene ID : | 1499 |
| mRNA Refseq : | NM_001098209 |
| Protein Refseq : | NP_001091679 |
| MIM : | 116806 |
| UniProt ID : | P35222 |
| Chromosome Location : | 3p21 |
| Pathway : | Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Basal cell carcinoma; Colorectal cancer; Endometrial cancer; Focal adhesion; Leukocyte transendothelial migration; Melanogenesis; Pathogenic Escherichia coli infection; Pathways in cancer; Prostate cancer; Thyroid cancer; Tight junction; Wnt signaling pathway; Apoptosis; Cell-cell adhesion systems; Signaling by Wnt |
| Function : | I-SMAD binding; alpha-catenin binding; androgen receptor binding; cadherin binding; chromatin binding; double-stranded DNA binding; kinase binding; promoter binding; protein C-terminus binding; protein phosphatase binding; signal transducer activity; transcription coactivator activity; transcription factor activity; transcription factor binding |
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