Recombinant Human CTNNB1,GST-tagged CTNNB1-1441H

Recombinant Human CTNNB1,GST-tagged

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Recombinant Human CTNNB1,GST-tagged

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Cat. No. : CTNNB1-1441H
Product Overview : Recombinant full-length human Catenin beta was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 115kDa.
Description : β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. β-catenin interacts with TCF and LEF transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3β, form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of β-catenin by the proteasome. APC and Siah-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1dow. :

Gene Name : CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [ Homo sapiens ]
Synonyms : CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; beta-catenin; Catenin beta-1; Beta-catenin
Gene ID : 1499
mRNA Refseq : NM_001098209
Protein Refseq : NP_001091679
MIM : 116806
UniProt ID : P35222
Chromosome Location : 3p21
Pathway : Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Basal cell carcinoma; Colorectal cancer; Endometrial cancer; Focal adhesion; Leukocyte transendothelial migration; Melanogenesis; Pathogenic Escherichia coli infection; Pathways in cancer; Prostate cancer; Thyroid cancer; Tight junction; Wnt signaling pathway; Apoptosis; Cell-cell adhesion systems; Signaling by Wnt
Function : I-SMAD binding; alpha-catenin binding; androgen receptor binding; cadherin binding; chromatin binding; double-stranded DNA binding; kinase binding; promoter binding; protein C-terminus binding; protein phosphatase binding; signal transducer activity; transcription coactivator activity; transcription factor activity; transcription factor binding

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