"BCL2L2" Related Products


Recombinant Human BCL2L2, His-tagged

Cat.No.: BCL2L2-26081TH
Product Overview: Recombinant fragment, corresponding to amino acids 1-172 of Human Bcl2L2 (minus the 17 amino acid C-terminus, the mitochondrial targeting sequence),and with a histidine tag on the C-terminus.M.Wt 18 kDa (monomer), ~25% exists as adisulfide-linked dimer.
Description: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Conjugation: HIS
Source: E. coli
Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or li
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Potassium chloride, 25mM HEPES, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: Amino acid sequencing indicates that the N-terminal methionine isremoved during expression in Escherichia coli.
Sequence Similarities: Belongs to the Bcl-2 family.
Gene Name: BCL2L2 BCL2-like 2 [ Homo sapiens ]
Official Symbol: BCL2L2
Synonyms: BCL2L2; BCL2-like 2; bcl-2-like protein 2; BCL W; KIAA0271; PPP1R51; protein phosphatase 1; regulatory subunit 51;
Gene ID: 599
mRNA Refseq: NM_001199839
Protein Refseq: NP_001186768
MIM: 601931
Uniprot ID: Q92843
Chromosome Location: 14q11.2-q12
Pathway: Apoptosis, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem;
Function: protein binding;

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