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Recombinant Human BMF, His-tagged

Cat.No.: BMF-26283TH
Product Overview: Recombinant full length Human Bmf isoform 3 , fused to 15 amino acid His Tag at the N-terminus, predicted MWt 15.6kDa including the tag.
Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein length: 129 amino acids
Conjugation: HIS
Molecular Weight: 15.600kDa inclusive of tags
Source: E. coli
Tissue specificity: Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 7.50Constituents:0.32% Tris HCl, 0.02% DTT, 10% Glycerol
Storage: Please see Notes section
Sequences of amino acids: MASMTGGQQM GRGSHMEPSQ CVEELEDDVF QPEDGEPVTQ PGSLLSADLF AQSLLDCPLS RLQLFPLTHC CGPGLRPTSQ EDKATQTLSPASPSQGVMLP CGVTEEPQRL FYAPAEPKSC VVADPPLPAQ PCFEWRREQE RGRP
Sequence Similarities: Belongs to the Bcl-2 family.
Gene Name: BMF Bcl2 modifying factor [ Homo sapiens ]
Official Symbol: BMF
Synonyms: BMF; Bcl2 modifying factor; bcl-2-modifying factor; FLJ00065;
Gene ID: 90427
mRNA Refseq: NM_033503
Protein Refseq: NP_277038
MIM: 606266
Uniprot ID: Q96LC9
Chromosome Location: 15q14
Pathway: Activation of BH3-only proteins, organism-specific biosystem; Activation of BMF and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem;
Function: protein binding;

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