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Recombinant Human C2

Cat.No. : C2-26739TH
Product Overview : Recombinant fragment of Human C2 with N terminal proprietary tag, 49kDa.
  • Specification
  • Gene Information
  • Related Products
Description : Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Molecular Weight : 49.000kDa
Source : E. coli
Form : Lyophilised:Add 200ul of distilled water.
Storage buffer : pH: 6.80Constituents:1.58% Tris HCl, 3.09% DTT, 4% SDS, 0.2% Bromophenol blue, 20% Sucrose
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.Contains 3 Sushi (CCP/SCR) domains.Contains 1 VWFA domain.
Gene Name : C2 complement component 2 [ Homo sapiens ]
Official Symbol : C2
Synonyms : C2; complement component 2; complement C2;
Gene ID : 717
mRNA Refseq : NM_000063
Protein Refseq : NP_000054
MIM : 613927
Uniprot ID : P06681
Chromosome Location : 6p21.3
Pathway : Activation of C3 and C5, organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem;
Function : peptidase activity; serine-type endopeptidase activity;

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◆ Lysates
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can C2 protein be a target for drug development in autoimmune disorders? 01/13/2023

Yes, drugs targeting C2 or the complement system are being explored as potential treatments for autoimmune diseases to regulate the immune response.

Can C2 protein be used as a diagnostic marker for immune system disorders? 05/18/2021

Yes, the absence or dysfunction of C2 protein can be indicative of immune system disorders, and its levels can be assessed for diagnostic purposes.

Can C2 protein be used in vaccine development? 06/21/2019

Understanding C2's role in immune activation may contribute to vaccine design, potentially enhancing the effectiveness of vaccines by targeting the complement system.

How does C2 protein contribute to autoimmune diseases? 11/26/2018

Abnormal activation of the complement system, including C2, is associated with some autoimmune diseases where the immune system mistakenly attacks the body's own cells.

Are there genetic factors influencing C2 protein levels and function? 05/27/2017

Yes, genetic variations can affect C2 protein expression and function, leading to variations in immune response among individuals.

Customer Reviews (3)

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Reviews
02/02/2023

    The C2 protein comes highly recommended for its excellent performance in various research applications.

    12/25/2020

      It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.

      05/08/2019

        Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.

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