Recombinant Human C2
Cat.No. : | C2-26739TH |
Product Overview : | Recombinant fragment of Human C2 with N terminal proprietary tag, 49kDa. |
- Specification
- Gene Information
- Related Products
Description : | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined. |
Molecular Weight : | 49.000kDa |
Source : | E. coli |
Form : | Lyophilised:Add 200ul of distilled water. |
Storage buffer : | pH: 6.80Constituents:1.58% Tris HCl, 3.09% DTT, 4% SDS, 0.2% Bromophenol blue, 20% Sucrose |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.Contains 3 Sushi (CCP/SCR) domains.Contains 1 VWFA domain. |
Gene Name : | C2 complement component 2 [ Homo sapiens ] |
Official Symbol : | C2 |
Synonyms : | C2; complement component 2; complement C2; |
Gene ID : | 717 |
mRNA Refseq : | NM_000063 |
Protein Refseq : | NP_000054 |
MIM : | 613927 |
Uniprot ID : | P06681 |
Chromosome Location : | 6p21.3 |
Pathway : | Activation of C3 and C5, organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; |
Function : | peptidase activity; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
C2-1143M | Recombinant Mouse C2 Protein, His (Fc)-Avi-tagged | +Inquiry |
C2-6878H | Active Recombinant Human C2 protein(Met1-Leu752), His-tagged | +Inquiry |
C2-7847R | Recombinant Rat C2 protein, His & T7-tagged | +Inquiry |
C2-7265H | Recombinant Human C2 protein, hFc-tagged | +Inquiry |
C2-1032H | Active Recombinant Human C2 protein, His-tagged | +Inquiry |
◆ Native Protein | ||
C2-98H | Active Native Human C2 Protein | +Inquiry |
◆ Lysates | ||
C2-3068HCL | Recombinant Human C2 cell lysate | +Inquiry |
C2-001MCL | Recombinant Mouse C2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, drugs targeting C2 or the complement system are being explored as potential treatments for autoimmune diseases to regulate the immune response.
Yes, the absence or dysfunction of C2 protein can be indicative of immune system disorders, and its levels can be assessed for diagnostic purposes.
Understanding C2's role in immune activation may contribute to vaccine design, potentially enhancing the effectiveness of vaccines by targeting the complement system.
Abnormal activation of the complement system, including C2, is associated with some autoimmune diseases where the immune system mistakenly attacks the body's own cells.
Yes, genetic variations can affect C2 protein expression and function, leading to variations in immune response among individuals.
Customer Reviews (3)
Write a reviewThe C2 protein comes highly recommended for its excellent performance in various research applications.
It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.
Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.
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