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Recombinant Human Moesin, GST-tagged

Cat.No. : MSN-1472H
Product Overview : Recombinant human Moesin (410-end) was expressed inE. colicells using an N-terminal GST tag. MW = 50kDa.
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Cat. No. : MSN-1472H
Description : Moesin (or membrane-organizing extension spike protein) belongs to ERM family that modulates epithelial integrity by regulating cell-signalling events that affect actin organization and polarity. The effects of Moesin on epithelial cells appear to result from inhibition of Rho signaling. ERM proteins serve a structural role in linkage of the cytoskeletion to the plasma membrane and the rescue of cells lacking Moesin by modulation of Rho signaling indicates that inhibition of Rho activity may be a more critical function of Moesin. The negative feedback loop produced by Rho"s activation of ERM may be an important mechanism that prevents the excessive migratory and invasive properties characteristic of metastatic cancer cells.
Source : E. coli.
Sequence : 410-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MSN moesin [ Homo sapiens ]
Synonyms : MSN; moesin
Gene ID : 4478
mRNA Refseq : NM_002444
Protein Refseq : NP_002435
MIM : 309845
UniProt ID : P26038
Chromosome Location : Xq11.1
Pathway : Leukocyte transendothelial migration; Regulation of actin cytoskeleton
Function : actin binding; cell adhesion molecule binding; receptor binding; structural constituent of cytoskeleton

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic strategies aimed at modulating MSN protein expression in cancer cells? 11/06/2022

Several therapeutic strategies are being explored to modulate MSN protein expression, including small molecule inhibitors and gene silencing techniques.

Can MSN protein be used as a biomarker for cancer detection? 09/14/2021

Research suggests that MSN protein levels can serve as a potential biomarker for cancer detection, offering a non-invasive method for early diagnosis.

Are there any ongoing clinical trials targeting MSN protein in cancer therapy? 02/04/2021

Yes, there are ongoing clinical trials investigating the efficacy of drugs targeting MSN protein in cancer treatment.

Are there any potential applications of MSN protein in regenerative medicine? 12/08/2020

MSN protein's role in cell structure and signaling makes it a potential candidate for applications in regenerative medicine, particularly in tissue engineering.

How does MSN protein influence cell migration and invasion in cancer cells? 09/09/2020

MSN protein plays a crucial role in promoting cell migration and invasion by facilitating the rearrangement of the actin cytoskeleton and promoting cellular motility.

Customer Reviews (3)

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Reviews
01/31/2021

    Its ease of use and versatility make it an excellent choice for various applications, including ELISA assays and protein electron microscopy structure analysis.

    01/22/2019

      I have consistently obtained outstanding results using the MSN Protein, which has significantly enhanced the efficiency and reliability of my research.

      09/28/2018

        Its exceptional performance and reliable outcomes make it an invaluable asset in advancing scientific understanding and uncovering important biological insights.

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