Recombinant Human Moesin, GST-tagged
Cat.No. : | MSN-1472H |
Product Overview : | Recombinant human Moesin (410-end) was expressed inE. colicells using an N-terminal GST tag. MW = 50kDa. |
- Specification
- Gene Information
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Cat. No. : | MSN-1472H |
Description : | Moesin (or membrane-organizing extension spike protein) belongs to ERM family that modulates epithelial integrity by regulating cell-signalling events that affect actin organization and polarity. The effects of Moesin on epithelial cells appear to result from inhibition of Rho signaling. ERM proteins serve a structural role in linkage of the cytoskeletion to the plasma membrane and the rescue of cells lacking Moesin by modulation of Rho signaling indicates that inhibition of Rho activity may be a more critical function of Moesin. The negative feedback loop produced by Rho"s activation of ERM may be an important mechanism that prevents the excessive migratory and invasive properties characteristic of metastatic cancer cells. |
Source : | E. coli. |
Sequence : | 410-end. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | MSN moesin [ Homo sapiens ] |
Synonyms : | MSN; moesin |
Gene ID : | 4478 |
mRNA Refseq : | NM_002444 |
Protein Refseq : | NP_002435 |
MIM : | 309845 |
UniProt ID : | P26038 |
Chromosome Location : | Xq11.1 |
Pathway : | Leukocyte transendothelial migration; Regulation of actin cytoskeleton |
Function : | actin binding; cell adhesion molecule binding; receptor binding; structural constituent of cytoskeleton |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSeveral therapeutic strategies are being explored to modulate MSN protein expression, including small molecule inhibitors and gene silencing techniques.
Research suggests that MSN protein levels can serve as a potential biomarker for cancer detection, offering a non-invasive method for early diagnosis.
Yes, there are ongoing clinical trials investigating the efficacy of drugs targeting MSN protein in cancer treatment.
MSN protein's role in cell structure and signaling makes it a potential candidate for applications in regenerative medicine, particularly in tissue engineering.
MSN protein plays a crucial role in promoting cell migration and invasion by facilitating the rearrangement of the actin cytoskeleton and promoting cellular motility.
Customer Reviews (3)
Write a reviewIts ease of use and versatility make it an excellent choice for various applications, including ELISA assays and protein electron microscopy structure analysis.
I have consistently obtained outstanding results using the MSN Protein, which has significantly enhanced the efficiency and reliability of my research.
Its exceptional performance and reliable outcomes make it an invaluable asset in advancing scientific understanding and uncovering important biological insights.
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